Ciro Santilli @cirosantilli 35

As of 2018, Ciro Santilli believes that this could be the next big thing in biology technology.

"De novo" means "starting from scratch", that is: you type the desired sequence into a computer, and the synthesize it.

The "de novo" part is important, because it distinguishes this from the already well solved problem of duplicating DNA from an existing DNA template, which is what all our cells do daily, and which can already be done very efficiently in vitro with polymerase chain reaction.

Many startup companies are attempting to create more efficient de novo synthesis methods:

Notably, the dream of most of those companies is to have a machine that sits on a lab bench, which synthesises whatever you want.

TODO current de novo synthesis costs/time to delivery after ordering a custom sequence.

The initial main applications are likely going to be:but the real pipe dream is building and bootstraping entire artificial chromosomes

News coverage:

This is the part of the formalization of mathematics that deals only with the propositions.

In some systems, e.g. including Metamath, modus ponens alone tends to be enough, everything else can be defined based on it.

There are two keywords that are killers: "news" and "world" and their translations or closely related words. Everything else is hard. So a good start is:

grep -e news -e noticias -e nouvelles -e world -e global

iran + football:

3 easy hits with "noticias" (news in Portuguese or Spanish"), uncovering two brand new ip ranges:

Let's see some French "nouvelles/actualites" for those tumultuous Maghrebis:

news + world:

news + global:

OK, I've decided to do a complete Wayback Machine CDX scanning of news... Searching for .JAR or https.*cgi-bin.*\.cgi are killers, particularly the .jar hits, here's what came out:

Wayback Machine CDX scanning of "world":

"headline": only 140 matches in 2013-dns-census-a-novirt.csv and 3 hits out of 269 hits. Full inspection without CDX led to no new hits.

"today": only 3.5k matches in 2013-dns-census-a-novirt.csv and 12 hits out of 269 hits, TODO how many on those on 2013-dns-census-a-novirt? No new hits.

"world", "global", "international", and spanish/portuguese/French versions like "mondo", "mundo", "mondi": 15k matches in 2013-dns-census-a-novirt.csv. No new hits.

A software that implements some database system, e.g. PostgreSQL or MySQL are two (widely extended) SQL implementations.

See: eigenvalues and eigenvectors.

First Amazon hire, wrote and led the team that wrote v1.

He looks like an older and more experienced dude compared to Bezos at the time.

Bibliography:
. www.geekwire.com/2011/meet-shel-kaphan-amazoncom-employee-1/2/ also mentions that unlike California, there's no sales tax in the state of Washington, which is important for selling books.

visualizing the Riemann hypothesis and analytic continuation by 3Blue1Brown (2016) is a good quick visual non-mathematical introduction is to it.

The key question is: how can this continuation be unique since we are defining the function outside of its original domain?

The answer is: due to the identity theorem.

Previously it was unclear if there were any .org hits, until we found the first one with clear comms: web.archive.org/web/20110624203548/http://awfaoi.org/hand.jar

Later on, two more clear ones were found with expired domain trackers:further settling their existence. Later on newimages.org also came to light.

Others that had been previously found in IP ranges but without clear comms:

.org is very rare, and has been excluded from some of our search heuristics. That was a shame, but likely not much was missed.

Ways in which it can happen: