Solexa Updated 2025-07-16
Instead of trying to dominate the sequencing market and gain trillions of dollars from it, they local British early stage investors were more than happy to get a 20x return on their small initial investments, and sold out to the Americans who will then make the real profit.
And now Solexa doesn't even have its own Wikipedia page, while Illumina is set out to be the next Microsoft. What a disgrace.
Cambridge visitors can still visit the Panton Arms pub, which was the location of the legendary "hey we should talk" founders meeting, chosen due to its proximity to the chemistry department of the University of Cambridge.
In 2021 the founders were awarded the Breakthrough Prize. The third person awarded was Pascal Mayer. He was apparently at Serono Pharmaceutical Research Institute at the time of development. They do have a wiki page unlike Solexa: en.wikipedia.org/wiki/Serono. They paid a 700 million fine in 2005 in the United States, and sold out in 2006 to Merck for 10 billion USD.
Bibliography:
- medium.com/@nick.mccooke/how-we-pioneered-next-generation-dna-sequencing-at-solexa-61bac41aedd2 How We Pioneered Next Generation DNA Sequencing At Solexal by Nick McCooke 2025. This article series could be very interesting.
smashkarts.io Updated 2025-07-16
Quite good, Ciro Santilli played this a lot in 2021/2022, his user ID: ofo5fNy7wRNC1Cw94YVB4KMOW5f2.
The physics not as good as the original Mario Kart 64, and it is notably missing jump gliding, and generally not as sharp! But it is really not bad.
Some of the weapons were too useless that you are just better firing them straight away at wall immediately to get something better, they could have a little better balancing there. I'm talking about you gatling that takes 10 seconds to finish firing, and does not kill enemies immediately. You are better off just firing that gun immediately when you get it to be able to get another gun ASAP. They seem to have done some balancing there however.
It had no chat option, but in a way it was cool to be forced to communicate non-verbally with people whose usernames you got familiar with. Funny you can love people like that, without ever talking to them. The best way of doing so being tea-bagging by going back and forth on a player after winning.
Slacktivism Updated 2025-07-16
Smiley's People (TV series) Updated 2025-07-16
This is perhaps slightly worse than the Tinker Tailor Soldier Spy, but still amazing.
Some difficult points:
- how did the general deduce that the old woman's daughter had a link to Karla? It must be linked to the fact that the Russian agent who made the offer was a Karla-man.
- some things are hard to understand without having seen the previous Tinker Tailor Soldier Spy, e.g. they say nothing clearly who Toby Esterhase is, he now works on art sales
- but others are inconsistent, e.g. they changed the actor for Peter Guillam...
Smiley's letter to Karla scene from Smiley's People 1982 BBC miniseries John le Carré adaptation EP6o
. Source. Fan-uplod by Ciro Santilli, one of the greatest television scenes ever. Blocked in the UK. Skills Other technologies Updated 2025-07-16
Skills Grading scale stoles from a Goolge interview Updated 2025-07-16
Skelet machine #1 Updated 2025-07-16
Single particle double slit experiment Updated 2025-07-16
This experiment seems to be really hard to do, and so there aren't many super clear demonstration videos with full experimental setup description out there unfortunately.
For single-photon non-double-slit experiments see: single photon production and detection experiments. Those are basically a pre-requisite to this.
photon experiments:
- aapt.scitation.org/doi/full/10.1119/1.4955173 "Video recording true single-photon double-slit interference" by Aspden and Padgetta (2016). Abstract says using spontaneous parametric down-conversion detection of the second photon to know when to turn the camera on
Non-elementary particle:
- 2019-10-08: 25,000 Daltons
- interactive.quantumnano.at/letsgo/ awesome interactive demo that allows you to control many parameters on a lab. Written in Flash unfortunately, in 2015... what a lack of future proofing!
Sequelize transaction retry Updated 2025-07-16
Transaction retries are inevitable, as some sQL isolation levels
Doesn't seem to have any simple built-in mechanism?
Separation of variables Updated 2025-07-16
Technique to solve partial differential equations
Naturally leads to the Fourier series, see: solving partial differential equations with the Fourier series, and to other analogous expansions:
One notable application is the solution of the Schrödinger equation via the time-independent Schrödinger equation.
Semiconductor equipment maker Updated 2025-07-16
As mentioned at youtu.be/16BzIG0lrEs?t=397 from Video "Applied Materials by Asianometry (2021)", originally the companies fabs would make their own equipment. But eventually things got so complicated that it became worth it for separate companies to focus on equipment, which then then sell to the fabs.
Semiconductor device fabrication Updated 2025-07-16
This is the lowest level of abstraction computer, at which the basic gates and power are described.
Secondary school Updated 2025-07-16
Scott Aaronson Updated 2025-07-16
Sci-Inspi (YouTube channel) Updated 2025-07-16
Science makes progress funeral by funeral Updated 2025-07-16
Science is the reverse engineering of nature Updated 2025-07-16
Ciro Santilli had once assigned this as one of Ciro Santilli's best random thoughts, but he later found that Wikipedia actually says exactly that: en.wikipedia.org/wiki/Reverse_engineering ("similar to scientific research, the only difference being that scientific research is about a natural phenomenon") so maybe that is where Ciro picked it up unconsciously in the first place.
Science fiction film Updated 2025-07-16
Schrödinger equation solution for the helium atom Updated 2025-07-16
No closed form solution, but good approximation that can be calculated by hand with the Hartree-Fock method, see hartree-Fock method for the helium atom.
Bibliography:
Schrödinger equation for a free one dimensional particle Updated 2025-07-16
Schrödinger equation for a one dimensional particle with . The first step is to calculate the time-independent Schrödinger equation for a free one dimensional particle
Then, for each energy , from the discussion at Section "Solving the Schrodinger equation with the time-independent Schrödinger equation", the solution is:Therefore, we see that the solution is made up of infinitely many plane wave functions.
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