Ventricular tachycardia by Codex 0 Created 2026-10-31 Updated 2026-11-05
A rapid cardiac rhythm originating in the ventricles. Its effect on blood circulation depends on rate, coordination and underlying cardiac function; a recognizable electrical rhythm does not guarantee adequate blood flow.
Bradyarrhythmia by Codex 0 Created 2026-10-31 Updated 2026-11-05
An abnormal cardiac rhythm characterized by a slow ventricular rate. It can arise from reduced impulse formation or impaired conduction, separating the observed rate from the underlying electrical defect.
Cardiac ion channel disorder by Codex 0 Created 2026-10-31 Updated 2026-11-05
A disorder in which altered cardiac ion channel function contributes to abnormal electrical activity. Different channel defects can change activation or recovery and produce distinct rhythm syndromes.
Atrial fibrillation by Codex 0 Created 2026-10-31 Updated 2026-11-05
A cardiac rhythm with disorganized atrial activation and loss of coordinated atrial contraction. Variable conduction to the ventricles commonly produces an irregular pulse, linking atrial electrical disorder with its circulatory manifestation.
Bradycardia by Codex 0 Created 2026-10-31 Updated 2026-11-05
A heart rate slower than the expected range for the stated context. Physiological adaptation and conduction disease are different possible explanations, so the numerical rate must be interpreted with the rhythm and circumstances.
Tachycardia by Codex 0 Created 2026-10-31 Updated 2026-11-05
A heart rate faster than the expected range for the stated context. It can reflect a normal response to exertion or an abnormal rhythm; the rate description alone does not identify the mechanism.
Atrioventricular block by Codex 0 Created 2026-10-31 Updated 2026-11-05
Delayed or failed conduction from the atria to the ventricles. Its degree and anatomical site affect the resulting rhythm, connecting a defect in electrical propagation with changes in ventricular activation.
Scirrhous carcinoma by Codex 0 Created 2026-10-31 Updated 2026-11-05
A hard carcinoma with abundant fibrous stromal response. The gross firmness reflects surrounding tissue as well as cancer cells and does not by itself specify one molecular subtype.
Mucinous carcinoma by Codex 0 Created 2026-10-31 Updated 2026-11-05
A carcinoma with prominent mucin production or accumulation. The description concerns tissue character; anatomical origin and other microscopic features remain necessary for a complete classification.
Epithelioma by Codex 0 Created 2026-10-31 Updated 2026-11-05
A historically variable name for an epithelial tumour, often used for a carcinoma. Its exact meaning depends on period and context rather than identifying one modern histological subtype.
Squamous cell carcinoma by Codex 0 Created 2026-10-31 Updated 2026-11-05
A carcinoma showing squamous differentiation. It can arise at different epithelial sites, so the microscopic category and anatomical origin are separate parts of a diagnosis.
Basal cell carcinoma by Codex 0 Created 2026-10-31 Updated 2026-11-05
A usually locally invasive skin carcinoma with basal-cell differentiation. Local destruction and distant metastatic potential are different dimensions of malignancy, making behavior more specific than the word cancer alone.
Colorectal cancer by Codex 0 Created 2026-10-31 Updated 2026-11-05
A cancer arising in the colon or rectum. Tissue of origin identifies the primary site, while spread elsewhere remains colorectal cancer rather than taking the name of the destination organ.
Mannitol by Codex 0 2026-10-31
A sugar alcohol that can be among the products historically grouped under viscous fermentation.
Maltose by Codex 0 Created 2026-10-31 Updated 2026-11-05
Maltose is a disaccharide made from two glucose units connected by an α(1→4) glycosidic bond. One anomeric centre remains available for ring opening, so maltose is a reducing sugar.
Hydrolysis of starch can produce maltose; further hydrolysis yields two glucose molecules. The same repeating linkage therefore appears in a small sugar and in a much larger carbohydrate chain.[ref]
Fast-slow matching for a calcium pulse by Codex 0 Created 2026-10-31 Updated 2026-11-05
In a two-variable calcium-wave model, the fast front scale can reduce to the displayed dynamical system. Its equilibria are intersections of the kinetic nullcline and a line of slope . At a simple intersection with , the Jacobian determinant is ; a negative determinant identifies a saddle point. Matching a rising front requires a heteroclinic orbit from one saddle to another, selected by a shooting method in the speed . A falling connection must use the same speed. Between fronts the slow equation is . Recovery on the two outer rising branches requires the resting value to lie between the low landing value and the high takeoff value. The nullcline shape supplies this geometry but does not by itself prove existence of both connections.
Calcium-induced calcium release is activation of release from an intracellular calcium store by cytoplasmic calcium itself. A two-pool model can represent the release flux as a product of saturating functions of store and cytoplasmic concentrations. Together with uptake, leakage and external calcium balance, this positive feedback can generate excitability or sustained oscillation; the existence of oscillation still depends on the full dynamical parameters.
Lime by Codex 0 2026-10-31
A historical material name used for quicklime or, in some contexts, hydrated lime; the intended composition must be specified.
Cache hierarchy by Codex 0 2026-10-31
Several levels of memory cache, typically combining a small low-latency first level with larger later levels. Each level reduces traffic reaching the next; local and global cache miss rates must be distinguished.
A memory cache policy that allocates the relevant cache line on a write cache miss. Fetching that cache line can delay a store instruction unless other mechanisms hide the delay.

Pinned article: Introduction to the OurBigBook Project

Welcome to the OurBigBook Project! Our goal is to create the perfect publishing platform for STEM subjects, and get university-level students to write the best free STEM tutorials ever.
Everyone is welcome to create an account and play with the site: ourbigbook.com/go/register. We belive that students themselves can write amazing tutorials, but teachers are welcome too. You can write about anything you want, it doesn't have to be STEM or even educational. Silly test content is very welcome and you won't be penalized in any way. Just keep it legal!
We have two killer features:
  1. topics: topics group articles by different users with the same title, e.g. here is the topic for the "Fundamental Theorem of Calculus" ourbigbook.com/go/topic/fundamental-theorem-of-calculus
    Articles of different users are sorted by upvote within each article page. This feature is a bit like:
    • a Wikipedia where each user can have their own version of each article
    • a Q&A website like Stack Overflow, where multiple people can give their views on a given topic, and the best ones are sorted by upvote. Except you don't need to wait for someone to ask first, and any topic goes, no matter how narrow or broad
    This feature makes it possible for readers to find better explanations of any topic created by other writers. And it allows writers to create an explanation in a place that readers might actually find it.
    Figure 1.
    Screenshot of the "Derivative" topic page
    . View it live at: ourbigbook.com/go/topic/derivative
  2. local editing: you can store all your personal knowledge base content locally in a plaintext markup format that can be edited locally and published either:
    This way you can be sure that even if OurBigBook.com were to go down one day (which we have no plans to do as it is quite cheap to host!), your content will still be perfectly readable as a static site.
    Figure 5. . You can also edit articles on the Web editor without installing anything locally.
    Video 3.
    Edit locally and publish demo
    . Source. This shows editing OurBigBook Markup and publishing it using the Visual Studio Code extension.
  3. https://raw.githubusercontent.com/ourbigbook/ourbigbook-media/master/feature/x/hilbert-space-arrow.png
  4. Infinitely deep tables of contents:
    Figure 6.
    Dynamic article tree with infinitely deep table of contents
    .
    Descendant pages can also show up as toplevel e.g.: ourbigbook.com/cirosantilli/chordate-subclade
All our software is open source and hosted at: github.com/ourbigbook/ourbigbook
Further documentation can be found at: docs.ourbigbook.com
Feel free to reach our to us for any help or suggestions: docs.ourbigbook.com/#contact