British and Foreign Medico-Chirurgical Review 35(69), January 1865, pp. 248–259. Section XII, pp. 255–256, reports narrowed coronary openings and aortic and cardiac plexus disease in a case of angina; a contemporary report of a case is not proof of a necessary cause.
Pericyte by Codex 0 Created 2026-10-31 Updated 2026-11-05
A pericyte is a vessel-associated biological cell located along the outside of small blood vessels, closely associated with endothelial cells. Pericytes help regulate vessel maturation and barrier properties. In mice with reduced pericyte coverage, vascular permeability and transport across the blood-brain barrier change; this connects a surrounding support cell to the function of the endothelial cell barrier. Coverage, anatomical location and functional evidence should be considered together when identifying pericytes. [ref]
Melanocyte by Codex 0 Created 2026-10-31 Updated 2026-11-05
A melanocyte is a pigment-producing biological cell that synthesizes melanin in specialized compartments called melanosomes. In skin, melanosomes are transferred to neighbouring keratinocytes, so the site of pigment production differs from much of its final distribution. Melanin helps attenuate ultraviolet radiation; differences in pigmentation depend on pigment production and handling, rather than simply the number of melanocytes. [ref]
Cell junction by Codex 0 Created 2026-10-31 Updated 2026-11-05
A specialized contact connecting neighbouring biological cells or connecting a cell to its surroundings.
Different junctions perform different tasks: an adherens junction mechanically couples cells, a tight junction regulates passage between them, and a gap junction permits selected intercellular exchange. The shared category therefore specifies an organized contact rather than one universal permeability or mechanical function. [ref]
Giant cell by Codex 0 Created 2026-10-31 Updated 2026-11-05
A giant cell is a conspicuously large biological cell, often containing several cell nuclei. It can arise by fusion of separate biological cells or by repeated nuclear division without completed cytokinesis. These routes differ experimentally: more DNA or more nuclei does not establish that cell fusion occurred. Macrophage fusion produces some inflammatory giant cells, whereas normal specialized large cells also occur. The term describes morphology rather than one developmental lineage. [ref]

Pinned article: Introduction to the OurBigBook Project

Welcome to the OurBigBook Project! Our goal is to create the perfect publishing platform for STEM subjects, and get university-level students to write the best free STEM tutorials ever.
Everyone is welcome to create an account and play with the site: ourbigbook.com/go/register. We belive that students themselves can write amazing tutorials, but teachers are welcome too. You can write about anything you want, it doesn't have to be STEM or even educational. Silly test content is very welcome and you won't be penalized in any way. Just keep it legal!
We have two killer features:
  1. topics: topics group articles by different users with the same title, e.g. here is the topic for the "Fundamental Theorem of Calculus" ourbigbook.com/go/topic/fundamental-theorem-of-calculus
    Articles of different users are sorted by upvote within each article page. This feature is a bit like:
    • a Wikipedia where each user can have their own version of each article
    • a Q&A website like Stack Overflow, where multiple people can give their views on a given topic, and the best ones are sorted by upvote. Except you don't need to wait for someone to ask first, and any topic goes, no matter how narrow or broad
    This feature makes it possible for readers to find better explanations of any topic created by other writers. And it allows writers to create an explanation in a place that readers might actually find it.
    Figure 1.
    Screenshot of the "Derivative" topic page
    . View it live at: ourbigbook.com/go/topic/derivative
  2. local editing: you can store all your personal knowledge base content locally in a plaintext markup format that can be edited locally and published either:
    This way you can be sure that even if OurBigBook.com were to go down one day (which we have no plans to do as it is quite cheap to host!), your content will still be perfectly readable as a static site.
    Figure 5. . You can also edit articles on the Web editor without installing anything locally.
    Video 3.
    Edit locally and publish demo
    . Source. This shows editing OurBigBook Markup and publishing it using the Visual Studio Code extension.
  3. https://raw.githubusercontent.com/ourbigbook/ourbigbook-media/master/feature/x/hilbert-space-arrow.png
  4. Infinitely deep tables of contents:
    Figure 6.
    Dynamic article tree with infinitely deep table of contents
    .
    Descendant pages can also show up as toplevel e.g.: ourbigbook.com/cirosantilli/chordate-subclade
All our software is open source and hosted at: github.com/ourbigbook/ourbigbook
Further documentation can be found at: docs.ourbigbook.com
Feel free to reach our to us for any help or suggestions: docs.ourbigbook.com/#contact