Topics (384k) Articles (398k) Users (410) Discussions (242) Comments (383) Files (13k) New article
Crossing between genetically distinct lineages or biological populations. It can introduce combinations of alleles into descendants and contribute to gene flow or hybrid speciation. This process is distinct from DNA hybridization, the pairing of complementary nucleic-acid strands.
A cyclic oligosaccharide host with a hydroxyl-rich exterior and a relatively nonpolar cavity. Different ring sizes recognize different organic guests through reversible inclusion. This node concerns its supramolecular chemistry.
A cyclic polyether host that can coordinate cations with inward-directed oxygen donors. Selectivity depends on donor arrangement, solvent and guest size, not ring size alone.
A hormone based on a steroid scaffold. Many act through an intracellular nuclear receptor to regulate gene expression.
An endogenous chemical regulator coordinating plant growth, development or environmental responses. Its effect depends on concentration, tissue and the receiving signal transduction network.
Maintenance of a tissue's organization and function despite continuing cell production and loss. Stable population size need not imply that its individual cells or constituent clones persist.
The fission-yeast histone methyltransferase responsible for H3K9 methylation. Its chromodomain couples recognition of an existing mark to further writing.
A histone methyltransferase contributing to repressive H3K9 methylation, including at targets associated with KAP1.
Removing repressive methylation helps restore expression competence after an environmental-history-dependent state. The example connects enzymatic reversal of a histone modification to resetting a developmental response between generations. [ref]
NCBI Gene by the National Library of Medicine. Arabidopsis thaliana, ELF6 record, Summary: histone demethylation
A core histone carrying several sites of regulatory modification, including the lysine modified in H3K9 methylation.
A histone associated with nucleosomal linker regions and higher-order organization, distinct from a member of the core histone octamer.
Pinned article: Introduction to the OurBigBook Project
Welcome to the OurBigBook Project! Our goal is to create the perfect publishing platform for STEM subjects, and get university-level students to write the best free STEM tutorials ever.
Everyone is welcome to create an account and play with the site: ourbigbook.com/go/register. We belive that students themselves can write amazing tutorials, but teachers are welcome too. You can write about anything you want, it doesn't have to be STEM or even educational. Silly test content is very welcome and you won't be penalized in any way. Just keep it legal!
Intro to OurBigBook
. Source. We have two killer features:
- topics: topics group articles by different users with the same title, e.g. here is the topic for the "Fundamental Theorem of Calculus" ourbigbook.com/go/topic/fundamental-theorem-of-calculusArticles of different users are sorted by upvote within each article page. This feature is a bit like:
- a Wikipedia where each user can have their own version of each article
- a Q&A website like Stack Overflow, where multiple people can give their views on a given topic, and the best ones are sorted by upvote. Except you don't need to wait for someone to ask first, and any topic goes, no matter how narrow or broad
This feature makes it possible for readers to find better explanations of any topic created by other writers. And it allows writers to create an explanation in a place that readers might actually find it.
Figure 1. Screenshot of the "Derivative" topic page. View it live at: ourbigbook.com/go/topic/derivativeVideo 2. OurBigBook Web topics demo. Source. - local editing: you can store all your personal knowledge base content locally in a plaintext markup format that can be edited locally and published either:This way you can be sure that even if OurBigBook.com were to go down one day (which we have no plans to do as it is quite cheap to host!), your content will still be perfectly readable as a static site.
- to OurBigBook.com to get awesome multi-user features like topics and likes
- as HTML files to a static website, which you can host yourself for free on many external providers like GitHub Pages, and remain in full control
Figure 2. You can publish local OurBigBook lightweight markup files to either OurBigBook.com or as a static website.
Figure 3. Visual Studio Code extension installation.
Figure 5. . You can also edit articles on the Web editor without installing anything locally. Video 3. Edit locally and publish demo. Source. This shows editing OurBigBook Markup and publishing it using the Visual Studio Code extension. 
- Infinitely deep tables of contents:
All our software is open source and hosted at: github.com/ourbigbook/ourbigbook
Further documentation can be found at: docs.ourbigbook.com
Feel free to reach our to us for any help or suggestions: docs.ourbigbook.com/#contact