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Building a cell cycle oscillator: hysteresis and bistability in the activation of Cdc2 by Joseph R. Pomerening and others by
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Published in Nature Cell Biology.
Cited passages: Pomerening et al. (2003), PDF p. 3, control discussion; p. 4, Figure 3h; reported 60–90 minute approach to apparent steady state; Pomerening, Sontag and Ferrell (2003), Building a cell cycle oscillator: hysteresis and bistability in the activation of Cdc2, PDF pp. 3–4, Figure 3a–c: history protocols and H1 readout; p. 6, Methods: phosphorimaging.
Precision and Kinetics of Adaptation in Bacterial Chemotaxis by Yigal Meir and others by
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Published in Biophysical Journal.
Online text: pmc.ncbi.nlm.nih.gov/articles/PMC2965943/
Cited passages: Meir et al. (2010), Introduction; Results, FRET data reveal qualitative differences between responses to addition/removal of attractant; Figure 2 and Methods: stimulus, bleaching compensation and imprecise adaptation; Meir, Jakovljevic, Oleksiuk, Sourjik and Wingreen (2010), Introduction and Figure 1: activity-dependent receptor modification.
Receptor sensitivity in bacterial chemotaxis by Victor Sourjik and others by
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Publisher: National Academy of Sciences.
Published in Proceedings of the National Academy of Sciences of the United States of America.
Online text: pmc.ncbi.nlm.nih.gov/articles/PMC117525/
Multiple Two-Photon Targeted Whole-Cell Patch-Clamp Recordings From Monosynaptically Connected Neurons in vivo by Jean-Sébastien Jouhanneau and others by
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Published in Frontiers in Synaptic Neuroscience.
Publisher: Frontiers.
Online text: www.frontiersin.org/journals/synaptic-neuroscience/articles/10.3389/fnsyn.2019.00015/full
Cited passages: Jouhanneau and Poulet (2019), Intracellular Current Injection: spontaneous activity, access resistance and voltage-estimation limits; Materials and Methods: anesthetized mice; Jouhanneau and Poulet (2019), Whole-Cell Pipettes and Electrophysiological Equipment; Step 4: Sealing; Step 5: Whole-Cell Configuration; Intracellular Current Injection.
Active propagation of somatic action potentials into neocortical pyramidal cell dendrites by Greg J. Stuart and others by
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Published in Nature.
Publisher: Nature.
Online text: www.nature.com/articles/367069a0
Cited passages: Stuart and Sakmann (1994), abstract: dendritic outside-out patches, current-pulse or synaptic stimulation, simultaneous whole-cell recordings and inferred direction of propagation; Stuart and Sakmann (1994), abstract: simultaneous soma–dendrite or soma–axon recordings, axonal initiation and active dendritic back-propagation.
Neuronal Dynamics: From Single Neurons to Networks and Models of Cognition by Wulfram Gerstner and others by
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Publisher: Cambridge University Press.
Anatomy and Physiology 2e by J. Gordon Betts and others by
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By J. Gordon Betts, Kelly A. Young, James A. Wise, Eddie Johnson, Brandon Poe, Dean H. Kruse, Oksana Korol, Jody E. Johnson, Mark Womble, Peter DeSaix.
Publisher: OpenStax.
Additional verified locator: section 6.3, Bone Structure, subsection Bone Cells and Tissue and Figures 6.11–6.12. The mineralized collagen matrix, bone-cell roles and lamellar organization distinguish living mineralized tissue from an inert mineral block. openstax.org/books/anatomy-and-physiology-2e/pages/6-3-bone-structure
Additional verified locator: section 19.1, Heart Anatomy, subsections Coronary Circulation and Coronary Arteries, Figure 19.15. Coronary arteries supply the myocardium and arise from the proximal aorta; the figure identifies the coronary surface vessels. openstax.org/books/anatomy-and-physiology-2e/pages/19-1-heart-anatomy
Additional verified locator: section 22.5, Transport of Gases, Oxygen Transport. Oxygen carried by hemoglobin and oxygen dissolved in blood are distinct from oxygen partial pressure; saturation describes hemoglobin binding rather than total oxygen amount. openstax.org/books/anatomy-and-physiology-2e/pages/22-5-transport-of-gases
Additional section 19.1 locators: Chambers and Circulation through the Heart, Right Atrium, Right Ventricle, and Coronary Veins. These subsections trace tricuspid/pulmonary outflow and distinguish coronary-sinus drainage from anterior cardiac veins that empty directly into the right atrium. openstax.org/books/anatomy-and-physiology-2e/pages/19-1-heart-anatomy
Additional verified locator: section 5.2, Accessory Structures of the Skin, Nails and Figure 5.13. The keratinized nail body, proliferating matrix and vascular nail bed explain growth, protection and back-support during manipulation. openstax.org/books/anatomy-and-physiology-2e/pages/5-2-accessory-structures-of-the-skin
Additional section 19.1 locators: External Anatomy and Figure 19.6 identify the surface sulci; Figure 19.9 shows the internal ventricular partition; Heart Valve Structure and Function, Figures 19.11–19.14, distinguishes valve leaflets, chordae and papillary support. openstax.org/books/anatomy-and-physiology-2e/pages/19-1-heart-anatomy
Additional section 19.1 locator: Left Atrium, describing pulmonary venous return, the mitral outlet, passive filling and the contribution of atrial contraction. openstax.org/books/anatomy-and-physiology-2e/pages/19-1-heart-anatomy
Additional precise §20.5 locators: openstax.org/books/anatomy-and-physiology-2e/pages/20-5-circulatory-pathways , The Superior Vena Cava and Table 20.11 (brachiocephalic and azygos return); The Inferior Vena Cava, Figure 20.40 and Table 20.15 (abdominal and hepatic tributaries); Veins Draining the Lower Limbs (common iliac veins joining the inferior vena cava). These add named systemic-vein locators to the earlier general/portal-circulation citation.
Additional locator: section 19.3, Cardiac Cycle, Pressures and Flow and Figure 19.27, distinguishes passive filling from coordinated atrial and ventricular contraction. openstax.org/books/anatomy-and-physiology-2e/pages/19-3-cardiac-cycle
Additional locator: section 20.2, Blood Flow, Blood Pressure, and Resistance, subsection A Mathematical Approach to Factors Affecting Blood Flow. The text separates volume flow from pressure and writes flow as pressure difference divided by resistance. openstax.org/books/anatomy-and-physiology-2e/pages/20-2-blood-flow-blood-pressure-and-resistance
Additional verified locator: section 22.3, The Process of Breathing, openstax.org/books/anatomy-and-physiology-2e/pages/22-3-the-process-of-breathing . Inspiration, pleural coupling and thoracic wall compliance distinguish chest-wall expansion from inward lung elastic recoil and connect wall mechanics with ventilation.
The Cell: A Molecular Approach, 2nd edition by Geoffrey M. Cooper by
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Online text: www.ncbi.nlm.nih.gov/books/NBK9890/
Patch-recorded single-channel currents of the purified and reconstituted Torpedo acetylcholine receptor by D. W. Tank and others by
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Online text: pubmed.ncbi.nlm.nih.gov/6308673/
Cited passages: Tank and colleagues, Patch-recorded single-channel currents of the purified and reconstituted Torpedo acetylcholine receptor (1983), primary abstract: purification, membrane reconstitution and functional single channels.
Neurotensin and acetylcholine evoke common responses in frog oocytes injected with rat brain messenger ribonucleic acid by C. Hirono and others by
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Online text: pmc.ncbi.nlm.nih.gov/articles/PMC1183039/
Cited passages: Hirono, Ito and Sugiyama, Neurotensin and acetylcholine evoke common responses in frog oocytes injected with rat brain messenger ribonucleic acid (1987), abstract points 1–8: expression preparation, voltage-clamp readout, latency, ion selectivity and intracellular perturbations.
Neuroscience, 2nd edition edited by D. Purves and others by
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Molecular Biology of the Cell, 4th edition by Bruce Alberts and others by
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Online section: Electron-Transport Chains and Their Proton Pumps.
Cited passages: Summary; H+ Ionophores Uncouple Electron Transport from ATP Synthesis; Respiratory Control Normally Restrains Electron Flow Through the Chain. The worker inspected official indexed text; direct Bookshelf access returned a browser challenge.
Additional section: DNA Repair.
Cited passages: Chapter 5, DNA Repair, Without DNA Repair, Spontaneous DNA Damage Would Rapidly Change DNA Sequences; Figures 5-46–5-49 and accompanying discussion. Whole-book authorship applies; no separate section byline is established. NCBI Bookshelf hosts the text. Indexed authored section text and figure captions were inspected; direct access returned a browser challenge.
Additional inspected fourth-edition sections, with no separate chapter bylines or revision dates established: Chapter 14, The Mitochondrion Contains an Outer Membrane, an Inner Membrane, and Two Internal Compartments, Figure 14-8, www.ncbi.nlm.nih.gov/books/NBK26894/; Chapter 12, The Transport of Proteins into Mitochondria and Chloroplasts, opening and Figure 12-22, www.ncbi.nlm.nih.gov/books/NBK26828/. Official indexed text was inspected; direct Bookshelf access returned a browser challenge. The existing whole-book authorship and 2002 publication date apply.
GTP-binding proteins couple cardiac muscarinic receptors to a K channel by P. J. Pfaffinger and others by
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Online text: pubmed.ncbi.nlm.nih.gov/2413367/
Cited passages: Pfaffinger, Martin, Hunter, Nathanson and Hille, GTP-binding proteins couple cardiac muscarinic receptors to a K channel (1985), primary abstract: intracellular GTP requirement, pertussis-toxin sensitivity, cyclic-nucleotide controls and 30–100 ms delays.
Elementary Steps in Synaptic Transmission Revealed by Currents through Single Ion Channels by Bert Sakmann by
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By Bert Sakmann.
Cited passages: Sakmann (1991), pp. 33–35 and Figure 1: local voltage clamp and patch-current recording; Sakmann, Elementary Steps in Synaptic Transmission Revealed by Currents through Single Ion Channels, Nobel lecture, 9 December 1991, pp. 33–35: preparation, voltage clamp, single-channel events and recording limits.
Researcher in molecular genetics and coauthor of the Meselson-Stahl experiment. Following isotopically labeled DNA across generations connected the distribution of old and new material with the mechanism of DNA replication.[ref]
The replication of DNA in Escherichia coli by Matthew Meselson and Franklin W. Stahl. Author list and described study
Researcher in molecular genetics and coauthor of the Meselson-Stahl experiment. Following isotopically labeled DNA across generations connected the distribution of old and new material with the mechanism of DNA replication.[ref]
The replication of DNA in Escherichia coli by Matthew Meselson and Franklin W. Stahl. Author list and described study
Portrait of Matthew Meselson
. Janet Montgomery. CC BY-SA 4.0, via Wikimedia Commons. Source.Researcher in microbial cell organization. Weibull used controlled lysozyme treatment to isolate protoplasts, connecting removal of the cell wall with study of the membrane-bounded cellular contents.[ref]
Coauthor of a chemical method for detecting DNA synthesis in living systems. The work connected incorporation of a modified precursor with selective labeling, making newly synthesized DNA distinguishable from pre-existing material.[ref]
Pinned article: Introduction to the OurBigBook Project
Welcome to the OurBigBook Project! Our goal is to create the perfect publishing platform for STEM subjects, and get university-level students to write the best free STEM tutorials ever.
Everyone is welcome to create an account and play with the site: ourbigbook.com/go/register. We belive that students themselves can write amazing tutorials, but teachers are welcome too. You can write about anything you want, it doesn't have to be STEM or even educational. Silly test content is very welcome and you won't be penalized in any way. Just keep it legal!
Intro to OurBigBook
. Source. We have two killer features:
- topics: topics group articles by different users with the same title, e.g. here is the topic for the "Fundamental Theorem of Calculus" ourbigbook.com/go/topic/fundamental-theorem-of-calculusArticles of different users are sorted by upvote within each article page. This feature is a bit like:
- a Wikipedia where each user can have their own version of each article
- a Q&A website like Stack Overflow, where multiple people can give their views on a given topic, and the best ones are sorted by upvote. Except you don't need to wait for someone to ask first, and any topic goes, no matter how narrow or broad
This feature makes it possible for readers to find better explanations of any topic created by other writers. And it allows writers to create an explanation in a place that readers might actually find it.Figure 1. Screenshot of the "Derivative" topic page. View it live at: ourbigbook.com/go/topic/derivativeVideo 2. OurBigBook Web topics demo. Source. - local editing: you can store all your personal knowledge base content locally in a plaintext markup format that can be edited locally and published either:This way you can be sure that even if OurBigBook.com were to go down one day (which we have no plans to do as it is quite cheap to host!), your content will still be perfectly readable as a static site.
- to OurBigBook.com to get awesome multi-user features like topics and likes
- as HTML files to a static website, which you can host yourself for free on many external providers like GitHub Pages, and remain in full control
Figure 2. You can publish local OurBigBook lightweight markup files to either OurBigBook.com or as a static website.Figure 3. Visual Studio Code extension installation.Figure 5. . You can also edit articles on the Web editor without installing anything locally. Video 3. Edit locally and publish demo. Source. This shows editing OurBigBook Markup and publishing it using the Visual Studio Code extension. - Infinitely deep tables of contents:
All our software is open source and hosted at: github.com/ourbigbook/ourbigbook
Further documentation can be found at: docs.ourbigbook.com
Feel free to reach our to us for any help or suggestions: docs.ourbigbook.com/#contact






