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A developmental regulator associated with variation in beak shape in Darwin's finches.[ref]
Evolution of Darwin's finches and their beaks revealed by genome sequencing by Sangeet Lamichhaney and others. ALX1-region association with beak morphology
A regulator of the positions of meiotic recombination hotspots in relevant mammals. An engineered DNA-binding region rescued fertility in a particular mouse hybrid cross.[ref]
Re-engineering the zinc fingers of PRDM9 reverses hybrid sterility in mice by Benjamin Davies and others. Figure 1 and hybrid-fertility rescue
A developmental transcription factor whose pelvic regulatory region provides an experimental example of localized cis-regulatory evolution in sticklebacks.[ref]
Adaptive evolution of pelvic reduction in sticklebacks by recurrent deletion of a Pitx1 enhancer by Yingguang Frank Chan and others. Pelvic enhancer deletion and restoration experiments
A conserved component implicated in the catalytic formation of programmed meiotic DNA double-strand breaks.[ref]
Meiosis-specific DNA double-strand breaks are catalyzed by Spo11, a member of a widely conserved protein family by Scott Keeney and others. Cell 88, pp. 375–384; biochemical identification
A coding sequence is the part of a nucleotide sequence that specifies a polypeptide through the genetic code. In a processed eukaryotic transcript it excludes untranslated regions; a genomic region may require removal of introns before bacterial expression.
v-src is the transforming src determinant carried by Rous sarcoma virus. Its product is a deregulated protein tyrosine kinase related to the normal cellular c-src product.
The MYC proto-oncogene regulates growth-associated gene-expression programmes. Retroviral promoter insertion near it provided an experimental example of transformation through deregulated expression of a cellular gene rather than carriage of a viral oncogene.
In the Pseudomonas aeruginosa pathway, aceA encodes isocitrate lyase. Its transcriptional regulation changes potential enzyme capacity, not uniquely the instantaneous metabolic flux.
In the Pseudomonas aeruginosa pathway, glcB encodes malate synthase. Its expression contributes to glyoxylate-shunt capacity.
The intestinal alkaline-phosphatase gene used to mark enterocyte-lineage progenitors in experimental fate-mapping systems. A driver's initially labelled biological population must be verified before interpreting long-lived descendants.
Pinned article: Introduction to the OurBigBook Project
Welcome to the OurBigBook Project! Our goal is to create the perfect publishing platform for STEM subjects, and get university-level students to write the best free STEM tutorials ever.
Everyone is welcome to create an account and play with the site: ourbigbook.com/go/register. We belive that students themselves can write amazing tutorials, but teachers are welcome too. You can write about anything you want, it doesn't have to be STEM or even educational. Silly test content is very welcome and you won't be penalized in any way. Just keep it legal!
Intro to OurBigBook
. Source. We have two killer features:
- topics: topics group articles by different users with the same title, e.g. here is the topic for the "Fundamental Theorem of Calculus" ourbigbook.com/go/topic/fundamental-theorem-of-calculusArticles of different users are sorted by upvote within each article page. This feature is a bit like:
- a Wikipedia where each user can have their own version of each article
- a Q&A website like Stack Overflow, where multiple people can give their views on a given topic, and the best ones are sorted by upvote. Except you don't need to wait for someone to ask first, and any topic goes, no matter how narrow or broad
This feature makes it possible for readers to find better explanations of any topic created by other writers. And it allows writers to create an explanation in a place that readers might actually find it.
Figure 1. Screenshot of the "Derivative" topic page. View it live at: ourbigbook.com/go/topic/derivativeVideo 2. OurBigBook Web topics demo. Source. - local editing: you can store all your personal knowledge base content locally in a plaintext markup format that can be edited locally and published either:This way you can be sure that even if OurBigBook.com were to go down one day (which we have no plans to do as it is quite cheap to host!), your content will still be perfectly readable as a static site.
- to OurBigBook.com to get awesome multi-user features like topics and likes
- as HTML files to a static website, which you can host yourself for free on many external providers like GitHub Pages, and remain in full control
Figure 2. You can publish local OurBigBook lightweight markup files to either OurBigBook.com or as a static website.
Figure 3. Visual Studio Code extension installation.
Figure 5. . You can also edit articles on the Web editor without installing anything locally. Video 3. Edit locally and publish demo. Source. This shows editing OurBigBook Markup and publishing it using the Visual Studio Code extension. 
- Infinitely deep tables of contents:
All our software is open source and hosted at: github.com/ourbigbook/ourbigbook
Further documentation can be found at: docs.ourbigbook.com
Feel free to reach our to us for any help or suggestions: docs.ourbigbook.com/#contact