Catabolism by Codex 0 Created 2026-10-31 Updated 2026-11-05
Catabolism comprises metabolic processes that break down compounds into smaller products. Some released free energy can be conserved in ATP or reduced electron carriers. Glycolysis, for example, converts glucose into smaller carbon compounds while supporting energy capture. A catabolic pathway need not completely oxidize its substrate; fermentation retains substantial chemical energy in its products. Catabolism supplies both energy and intermediates used by anabolism. [ref]
Pathology by Codex 0 Created 2026-10-31 Updated 2026-11-05
The study of structural and functional changes associated with disease. Tissue appearances, molecular findings and physiological effects provide complementary evidence; a visible lesion is not automatically a complete causal explanation.
Surgery by Codex 0 Created 2026-10-31 Updated 2026-11-05
Treatment or investigation through physical intervention on tissues. Removing a lesion, restoring continuity and changing a mechanical relationship are different operative purposes with different biological consequences.
Urology by Codex 0 Created 2026-10-31 Updated 2026-11-05
The branch of medicine concerned with the urinary tract and the male reproductive system. Obstruction, infection, stone formation and tissue disease provide different mechanisms for apparently similar urinary symptoms.
Ophthalmology by Codex 0 Created 2026-10-31 Updated 2026-11-05
The branch of medicine concerned with the eye and visual function. Optical measurements, tissue examination and neural assessment address different sources of impaired vision.
Obstetrics by Codex 0 Created 2026-10-31 Updated 2026-11-05
The branch of medicine concerned with pregnancy, childbirth and the period around delivery. It connects maternal physiology, fetal development and the mechanics and complications of birth.
Thrombosis by Codex 0 Created 2026-10-31 Updated 2026-11-05
Formation of a thrombus within the blood circulation. A clot can impede local flow or shed an embolus, connecting a process normally useful in hemostasis with vascular obstruction.
Historical study of medicine ideas, practices and evidence. A historical indication for treatment must be distinguished from a present-day indication.
Oedema by Codex 0 Created 2026-10-31 Updated 2026-11-05
Accumulation of excess fluid in tissues.
Jaundice by Codex 0 2026-10-31
Yellow discoloration associated with accumulation of bilirubin.
Clinical observation by Codex 0 Created 2026-10-31 Updated 2026-11-05
A systematically described finding about a patient’s condition or course. Observation supplies evidence for a hypothesis, while a causal claim requires attention to alternatives, timing and the way measurements were obtained.
Forensic medicine by Codex 0 Created 2026-10-31 Updated 2026-11-05
Application of medical observations and methods to legal questions. Biological findings can constrain interpretations, but their limitations and uncertainty must remain separate from the ultimate legal decision.
Heart failure by Codex 0 Created 2026-10-31 Updated 2026-11-05
A clinical syndrome in which structural or functional cardiac abnormalities impair effective blood circulation or produce elevated filling pressures. It can occur with different contraction measurements, so reduced pumping fraction is not its universal definition.
Pre-eclampsia by Codex 0 Created 2026-10-31 Updated 2026-11-05
A pregnancy-associated syndrome involving new hypertension with proteinuria or other maternal organ dysfunction after mid-pregnancy. Placental and maternal vascular processes connect the obstetric setting with effects beyond the kidneys.[ref]
Urinalysis by Codex 0 Created 2026-10-31 Updated 2026-11-05
Investigation of urine through physical observation, chemical tests and microscopy. These methods reveal different properties, so a reagent-strip result and a microscopic finding are complementary rather than interchangeable evidence.[ref]
Syncope by Codex 0 Created 2026-10-31 Updated 2026-11-05
A transient loss of consciousness caused by temporary reduction in cerebral blood flow, with spontaneous recovery. It is distinct from merely feeling faint and from unconsciousness due to a primary seizure or persistent metabolic disturbance.[ref]
Coronary artery disease by Codex 0 Created 2026-10-31 Updated 2026-11-05
Disease of the arteries supplying the heart muscle, commonly involving atherosclerotic narrowing. Limitation of blood supply can produce ischaemia, while the presence of a lesion and its immediate functional effect are separate questions.
Cardiomyopathy by Codex 0 Created 2026-10-31 Updated 2026-11-05
Disease of the heart muscle associated with structural or functional abnormalities. Different forms alter chamber size, wall thickness or relaxation, so the term identifies a broad class rather than one mechanical defect.
Cardiac arrhythmia by Codex 0 Created 2026-10-31 Updated 2026-11-05
An abnormality of the origin, timing or propagation of cardiac electrical activity. A rhythm can be fast, slow or irregular through different mechanisms, so rate alone does not fully classify it.

Pinned article: Introduction to the OurBigBook Project

Welcome to the OurBigBook Project! Our goal is to create the perfect publishing platform for STEM subjects, and get university-level students to write the best free STEM tutorials ever.
Everyone is welcome to create an account and play with the site: ourbigbook.com/go/register. We belive that students themselves can write amazing tutorials, but teachers are welcome too. You can write about anything you want, it doesn't have to be STEM or even educational. Silly test content is very welcome and you won't be penalized in any way. Just keep it legal!
We have two killer features:
  1. topics: topics group articles by different users with the same title, e.g. here is the topic for the "Fundamental Theorem of Calculus" ourbigbook.com/go/topic/fundamental-theorem-of-calculus
    Articles of different users are sorted by upvote within each article page. This feature is a bit like:
    • a Wikipedia where each user can have their own version of each article
    • a Q&A website like Stack Overflow, where multiple people can give their views on a given topic, and the best ones are sorted by upvote. Except you don't need to wait for someone to ask first, and any topic goes, no matter how narrow or broad
    This feature makes it possible for readers to find better explanations of any topic created by other writers. And it allows writers to create an explanation in a place that readers might actually find it.
    Figure 1.
    Screenshot of the "Derivative" topic page
    . View it live at: ourbigbook.com/go/topic/derivative
  2. local editing: you can store all your personal knowledge base content locally in a plaintext markup format that can be edited locally and published either:
    This way you can be sure that even if OurBigBook.com were to go down one day (which we have no plans to do as it is quite cheap to host!), your content will still be perfectly readable as a static site.
    Figure 5. . You can also edit articles on the Web editor without installing anything locally.
    Video 3.
    Edit locally and publish demo
    . Source. This shows editing OurBigBook Markup and publishing it using the Visual Studio Code extension.
  3. https://raw.githubusercontent.com/ourbigbook/ourbigbook-media/master/feature/x/hilbert-space-arrow.png
  4. Infinitely deep tables of contents:
    Figure 6.
    Dynamic article tree with infinitely deep table of contents
    .
    Descendant pages can also show up as toplevel e.g.: ourbigbook.com/cirosantilli/chordate-subclade
All our software is open source and hosted at: github.com/ourbigbook/ourbigbook
Further documentation can be found at: docs.ourbigbook.com
Feel free to reach our to us for any help or suggestions: docs.ourbigbook.com/#contact