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Researcher in early mammalian development. Chazaud and collaborators investigated the Grb2–MAPK pathway in segregation of epiblast and primitive endoderm in mouse blastocysts, connecting signaling with early cell-fate decisions.[ref]
Researcher in early human development. Roode and collaborators studied hypoblast formation and its independence from FGF signaling under the tested conditions, demonstrating the importance of checking species-specific developmental mechanisms.[ref]
Human hypoblast formation is not dependent on FGF signalling by Mila Roode and others. Title, author list and reported study
Researcher in early human development. Blakeley and collaborators used single-cell RNA sequencing to distinguish the three cell lineages of the human blastocyst, connecting developmental identity with molecular expression profiles.[ref]
Researcher in early mammalian development. Simon and collaborators investigated how suppression of ERK signaling promotes pluripotent epiblast in the human blastocyst, connecting a signaling perturbation with maintenance of an embryonic cell state.[ref]
Researcher in vertebrate segmentation. Palmeirim and collaborators investigated oscillatory avian hairy-gene expression, providing evidence for a molecular clock associated with somitogenesis.[ref]
Researcher in vertebrate development. With Olivier Pourquié, Iimura examined ordered Hoxb activation during gastrulation, connecting regulation of positional identity with the entry of cells into mesoderm.[ref]
Researcher in vertebrate development. With Tadahiro Iimura, Pourquié investigated the connection between ordered Hoxb activation and mesodermal ingression during gastrulation, linking gene-expression timing with movements of developing tissue.[ref]
Researcher in developmental gene regulation. Clark and collaborators investigated how a sequence of transcription factors organizes insect segmentation, connecting the timing of regulatory activity with spatial pattern formation.[ref]
Researcher in insect development. With Erik Clark, Akam studied how Odd-paired changes the pair-rule regulatory network in Drosophila, connecting a change in gene interactions with a change in pattern periodicity.[ref]
Researcher in insect development and evolution. With Erik Clark, Peel investigated temporal regulation of segmentation through a conserved sequence of transcription factors, connecting developmental timing with repeated body-pattern formation.[ref]
Researcher in developmental biology. With Ruth Lehmann, Ephrussi investigated induction of germ-cell formation by Oskar, connecting spatially organized molecular information with establishment of a reproductive cell lineage.[ref]
Induction of germ cell formation by oskar by Anne Ephrussi and Ruth Lehmann. Title, author list and reported study
Researcher in germ-cell development. With Anne Ephrussi, Lehmann studied induction of germ-cell formation by Oskar, connecting the location and activity of an inherited developmental regulator with formation of the germline.[ref]
Induction of germ cell formation by oskar by Anne Ephrussi and Ruth Lehmann. Title, author list and reported study
Researcher in germ-cell gene regulation. Hanyu-Nakamura and collaborators investigated how the Drosophila Pgc protein inhibits recruitment of a transcriptional regulator to chromatin, connecting a germline-specific factor with reduced transcriptional activity.[ref]
Researcher in gene regulation during development. Batchelder and collaborators investigated transcriptional repression by PIE-1 in the Caenorhabditis elegans germline, connecting suppression of somatic programs with maintenance of germ-cell identity.[ref]
Researcher in embryonic development. Lawson and collaborators investigated the requirement for BMP4 in generating mouse primordial germ cells, connecting a signaling molecule with specification of the future reproductive lineage.[ref]
Researcher in germ-cell development. Magnúsdóttir and collaborators investigated a three-component transcription factor network controlling primordial germ-cell specification in mice, connecting combinatorial regulation with acquisition of a developmental fate.[ref]
Researcher in germ-cell development. Irie and collaborators investigated SOX17 as a determinant of human primordial germ-cell fate, showing why a regulatory program established in one species need not transfer unchanged to another.[ref]
SOX17 is a critical specifier of human primordial germ cell fate by Naoko Irie and others. Title, author list and reported study
Researcher in comparative vertebrate biology. With R. Glenn Northcutt, GaNs developed the new-head hypothesis, connecting the neural crest and associated developmental innovations with the origin of vertebrate features.[ref]
Neural crest and the origin of vertebrates: a new head by Carl Gans and R. Glenn Northcutt. Title, author list and reported study
Researcher in vertebrate evolution. With Carl Gans, Northcutt proposed that the neural crest helped generate a new head organization, connecting embryonic cell populations with major changes in vertebrate anatomy.[ref]
Neural crest and the origin of vertebrates: a new head by Carl Gans and R. Glenn Northcutt. Title, author list and reported study
Researcher in craniofacial development. With Jill A. Helms, Schneider investigated how cellular and molecular programs specify beak morphology, linking embryonic tissue behavior with species-specific anatomy.[ref]
The cellular and molecular origins of beak morphology by Richard A. Schneider and Jill A. Helms. Title, author list and reported study
Pinned article: Introduction to the OurBigBook Project
Welcome to the OurBigBook Project! Our goal is to create the perfect publishing platform for STEM subjects, and get university-level students to write the best free STEM tutorials ever.
Everyone is welcome to create an account and play with the site: ourbigbook.com/go/register. We belive that students themselves can write amazing tutorials, but teachers are welcome too. You can write about anything you want, it doesn't have to be STEM or even educational. Silly test content is very welcome and you won't be penalized in any way. Just keep it legal!
Intro to OurBigBook
. Source. We have two killer features:
- topics: topics group articles by different users with the same title, e.g. here is the topic for the "Fundamental Theorem of Calculus" ourbigbook.com/go/topic/fundamental-theorem-of-calculusArticles of different users are sorted by upvote within each article page. This feature is a bit like:
- a Wikipedia where each user can have their own version of each article
- a Q&A website like Stack Overflow, where multiple people can give their views on a given topic, and the best ones are sorted by upvote. Except you don't need to wait for someone to ask first, and any topic goes, no matter how narrow or broad
This feature makes it possible for readers to find better explanations of any topic created by other writers. And it allows writers to create an explanation in a place that readers might actually find it.
Figure 1. Screenshot of the "Derivative" topic page. View it live at: ourbigbook.com/go/topic/derivativeVideo 2. OurBigBook Web topics demo. Source. - local editing: you can store all your personal knowledge base content locally in a plaintext markup format that can be edited locally and published either:This way you can be sure that even if OurBigBook.com were to go down one day (which we have no plans to do as it is quite cheap to host!), your content will still be perfectly readable as a static site.
- to OurBigBook.com to get awesome multi-user features like topics and likes
- as HTML files to a static website, which you can host yourself for free on many external providers like GitHub Pages, and remain in full control
Figure 2. You can publish local OurBigBook lightweight markup files to either OurBigBook.com or as a static website.
Figure 3. Visual Studio Code extension installation.
Figure 5. . You can also edit articles on the Web editor without installing anything locally. Video 3. Edit locally and publish demo. Source. This shows editing OurBigBook Markup and publishing it using the Visual Studio Code extension. 
- Infinitely deep tables of contents:
All our software is open source and hosted at: github.com/ourbigbook/ourbigbook
Further documentation can be found at: docs.ourbigbook.com
Feel free to reach our to us for any help or suggestions: docs.ourbigbook.com/#contact