Topics (384k) Articles (398k) Users (410) Discussions (242) Comments (383) Files (13k) New article
Researcher in cancer biology. Tsai and collaborators investigated when and where epithelial-to-mesenchymal transition contributes to squamous-cell carcinoma metastasis, connecting a change of cell state with different stages of dissemination.[ref]
Researcher in cancer cell-state transitions. Pastushenko and collaborators identified intermediate states during epithelial-to-mesenchymal transition, showing why a simple two-state description can miss biologically distinct populations.[ref]
Researcher in cancer biology. Fischer and collaborators investigated the contribution of epithelial-to-mesenchymal transition to lung metastasis and drug resistance, separating processes that can occur together but have different functional requirements.[ref]
Researcher in immunotherapy. Rohaan and collaborators compared tumor-infiltrating lymphocyte therapy with ipilimumab in advanced melanoma, directly testing alternative treatment strategies rather than inferring benefit from immune activity alone.[ref]
Researcher in tumor immunology. Mariathasan and collaborators investigated how TGF-beta signalling signaling contributes to exclusion of T cells and a reduced response to PD-L1 blockade, connecting the tumour microenvironment with treatment response.[ref]
Researcher studying resistance to immune checkpoint blockade. Zaretsky and collaborators investigated acquired resistance to PD-1 blockade in melanoma, connecting changes in tumor cells with loss of therapeutic response.[ref]
Author of comparative research on human and rat pancreatic beta cells. The study distinguished differences in glucose transporter expression from glucokinase expression, helping specify which parts of glucose sensing vary between species.[ref]
Researcher in nucleic acid structural biology. Wang and collaborators determined an atomic structure of a left-handed double-helical DNA fragment, establishing a concrete alternative to the familiar right-handed form.[ref]
Researcher in cell cycle control. Murray and collaborators investigated how cyclin synthesis and destruction regulate maturation-promoting factor, connecting periodic protein turnover with progression through division.[ref]
Researcher in bacterial structural biology. Briegel and collaborators investigated the shared architecture of bacterial chemoreceptor arrays, connecting the organization of signaling proteins with chemotaxis.[ref]
Universal architecture of bacterial chemoreceptor arrays by Ariane Briegel and others. Title, author list and reported study
Researcher in metabolic disease. Glaser and collaborators identified an activating glucokinase mutation associated with familial hyperinsulinism, connecting altered glucose sensing with inappropriate insulin release.[ref]
Familial Hyperinsulinism Caused by an Activating Glucokinase Mutation by Benjamin Glaser and others. Title, author list and reported study
Researcher in structural biology. Benoff and collaborators studied a complex of catabolite activator protein, the RNA-polymerase alpha-subunit domain and DNA, connecting physical contacts with bacterial transcription activation.[ref]
Immunologist who, with Georges Köhler, developed continuously growing antibody-producing fused cells. This approach made reproducible monoclonal antibodies available for experiments that require one defined binding specificity.[ref]
Researcher in biophysical measurement. Some and collaborators described combining size-exclusion chromatography with multi-angle light scattering to characterize proteins, connecting separation by solution behavior with a mass-sensitive measurement.[ref]
Researcher in enzyme design. Röthlisberger and collaborators investigated computationally designed catalysts for Kemp elimination, testing whether a proposed catalytic geometry could produce measurable chemical activity.[ref]
Kemp elimination catalysts by computational enzyme design by Daniela Röthlisberger and others. Title, author list and reported study
Researcher in structural biology. Doyle and collaborators determined a potassium channel structure, connecting atomic organization with the molecular explanation of selective potassium conduction.[ref]
Researcher in molecular biology. Studier and collaborators used bacteriophage T7 RNA polymerase to direct high expression of cloned genes, exploiting selective promoter recognition to control recombinant protein production.[ref]
Immunologist who, with César Milstein, established continuously growing fused cells secreting an antibody of predefined specificity. Their work supplied the basis of hybridoma production of monoclonal antibodies.[ref]
Pinned article: Introduction to the OurBigBook Project
Welcome to the OurBigBook Project! Our goal is to create the perfect publishing platform for STEM subjects, and get university-level students to write the best free STEM tutorials ever.
Everyone is welcome to create an account and play with the site: ourbigbook.com/go/register. We belive that students themselves can write amazing tutorials, but teachers are welcome too. You can write about anything you want, it doesn't have to be STEM or even educational. Silly test content is very welcome and you won't be penalized in any way. Just keep it legal!
Intro to OurBigBook
. Source. We have two killer features:
- topics: topics group articles by different users with the same title, e.g. here is the topic for the "Fundamental Theorem of Calculus" ourbigbook.com/go/topic/fundamental-theorem-of-calculusArticles of different users are sorted by upvote within each article page. This feature is a bit like:
- a Wikipedia where each user can have their own version of each article
- a Q&A website like Stack Overflow, where multiple people can give their views on a given topic, and the best ones are sorted by upvote. Except you don't need to wait for someone to ask first, and any topic goes, no matter how narrow or broad
This feature makes it possible for readers to find better explanations of any topic created by other writers. And it allows writers to create an explanation in a place that readers might actually find it.
Figure 1. Screenshot of the "Derivative" topic page. View it live at: ourbigbook.com/go/topic/derivativeVideo 2. OurBigBook Web topics demo. Source. - local editing: you can store all your personal knowledge base content locally in a plaintext markup format that can be edited locally and published either:This way you can be sure that even if OurBigBook.com were to go down one day (which we have no plans to do as it is quite cheap to host!), your content will still be perfectly readable as a static site.
- to OurBigBook.com to get awesome multi-user features like topics and likes
- as HTML files to a static website, which you can host yourself for free on many external providers like GitHub Pages, and remain in full control
Figure 2. You can publish local OurBigBook lightweight markup files to either OurBigBook.com or as a static website.
Figure 3. Visual Studio Code extension installation.
Figure 5. . You can also edit articles on the Web editor without installing anything locally. Video 3. Edit locally and publish demo. Source. This shows editing OurBigBook Markup and publishing it using the Visual Studio Code extension. 
- Infinitely deep tables of contents:
All our software is open source and hosted at: github.com/ourbigbook/ourbigbook
Further documentation can be found at: docs.ourbigbook.com
Feel free to reach our to us for any help or suggestions: docs.ourbigbook.com/#contact