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Tetrahydrofuran is a cyclic ether solvent. Its oxygen can coordinate lithium ions and alter the aggregation of organolithium reagents.
Tetrahydrofuran is a cyclic ether solvent. Its oxygen can coordinate lithium ions and alter the aggregation of organolithium reagents.
Tetrahydrofuran is a cyclic ether solvent. Its oxygen can coordinate lithium ions and alter the aggregation of organolithium reagents.
William S. Johnson developed a stereoselective orthoester variant of the Claisen rearrangement. The 1970 report connects the method with formation of trans-trisubstituted carbon–carbon double bonds and the synthesis of squalene.[ref]
Simple stereoselective version of the Claisen rearrangement by William S. Johnson and colleagues. 1970, full title and original orthoester Claisen method
Jeffrey M. Robertson used model reactions to investigate intermediates in liquid-crystal polymer synthesis. Trapping experiments with secondary amines supported formation of a quinoid ketene through E1cb elimination, connecting a proposed intermediate with an observable product.[ref]
Model experiments implicate a benzoquinoneketene intermediate in LCP synthesis by Jeffrey M. Robertson and colleagues. 2011, hydroxybenzoyl ester models, E1cB fragmentation and secondary-amine trapping
Robert Burns Woodward developed strategies for the total synthesis of structurally complex natural products. His 1965 Nobel lecture uses the synthesis of cephalosporin C to explain the problems of constructing a target's carbon skeleton, arranging functional groups, and controlling stereochemistry. The synthesis becomes an argument about molecular structure as well as a route to a substance.[ref]
https://www.nobelprize.org/uploads/2018/06/woodward-lecture.pdf. Recent Advances in the Chemistry of Natural Products, 1965: cephalosporin C synthesis
Portrait of Robert Burns Woodward
. Dr. Peter Geymayer; derivative work by Chamal. Public domain. Source usage terms, via Wikimedia Commons. Source.Roald Hoffmann developed the isolobal analogy, relating molecular fragments through their frontier orbitals. Comparable number, symmetry, shape, energy, and occupation of these orbitals can suggest related bonding patterns.
This connects inorganic and organic chemistry without claiming that equal total electron counts guarantee identical reactivity. The analogy concerns the orbitals available to make bonds.[ref]
Building Bridges Between Inorganic and Organic Chemistry (Nobel Lecture) by Roald Hoffmann. Nobel lecture: isolobal correspondence
Portrait of Roald Hoffmann
. Armin Kübelbeck. CC BY-SA 3.0, via Wikimedia Commons. Source.Matthias Hofmann combined computational chemistry with NMR spectroscopy to resolve the solution structure of an arachno borane anion. Comparing calculated structures and NMR behaviour identified a fluxional structure and distinguished the lowest-energy form from an intermediate involved in rearrangement.[ref]
The Structure of arachno-B6H11-, at -25 degrees C in (CD3)2O, Is Resolved via the ab Initio IGLO-GIAO NMR Procedure by Matthias Hofmann and others. 2000, abstract: arachno-B6H11 anion, computed minima and fluxional intermediate
Americium is the chemical element with atomic number 95 and symbol . It is a actinide. It has no stable isotopes. Americium-241 is an alpha emitter used in some ionization smoke detectors, where the radiation maintains a small electrical current that smoke particles disturb.
A metal-metal bond joins two metal centers directly through overlap of their atomic orbitals. A single bond contributes one electron to the local count at each metal in conventional electron counting. Bridging ligands can accompany direct bonding, but a short bridged separation alone does not establish its bond order.
Thomas P. Onak coauthored research on carborane.[ref]
Synthesis of Carboranes from Dihydrocarboranes by Thomas P. Onak and others. publication title and author list
Robert E. Ireland developed synthetic uses of the ester-enolate Claisen rearrangement, now called the Ireland–Claisen rearrangement. Allylic esters are converted to enolates or silyl ketene acetals before a concerted rearrangement forms a new carbon-carbon bond.
Control of enolate geometry helps control product stereochemistry. The transformation therefore illustrates how stereochemical information introduced in one preparation step can guide bond formation in a later step.[ref]
https://doi.org/10.1021/jo00868a018. Ester enolate Claisen rearrangement: construction of the prostanoid skeleton, primary publication
Otto Diels and Kurt Alder developed the Diels-Alder reaction, a cycloaddition joining a diene with pi conjugation with a dienophile. Its usefulness comes from building a six-membered ring while preserving a predictable relationship between the starting materials' spatial arrangement and the product's stereochemistry.[ref]
Diene synthesis and related reaction types by Kurt Alder. Diene synthesis and related reaction types, 1950: diene synthesis and stereochemical relationships
Portrait of Otto Diels
. Unknown author; Nobel Foundation. Public domain. Source usage terms, via Wikimedia Commons. Source.Kurt Alder and Otto Diels developed the Diels-Alder reaction, in which a diene with pi conjugation and a dienophile combine to build a six-membered ring. The transformation creates two carbon–carbon chemical bonds in one ring-forming step, explaining its importance in constructing complex organic molecules.[ref]
Diene synthesis and related reaction types by Kurt Alder. Diene synthesis and related reaction types, Nobel lecture, 12 December 1950
Portrait of Kurt Alder
. Unknown author; Nobel Foundation. Public domain. Source usage terms, via Wikimedia Commons. Source.Makoto Kumada helped develop cross-coupling reaction between Grignard reagents and organic organohalogen compounds using nickel–phosphine complexes as catalysts. The method joins two carbon-containing fragments by a new carbon–carbon chemical bond, making an organomagnesium reagent useful for carbon-skeleton construction.[ref]
https://doi.org/10.1016/S0022-328X(02)01159-2. Discovery account by Kohei Tamao, abstract: 1972 nickel–phosphine-catalysed coupling
Portrait of Makoto Kumada
. Chem-Station credits titech.ac.jp for the photograph. Source.A reduction decreases an oxidation state, recording gain in the formal electron assignment. For , the decrease is . The reduced chemical species serves as the oxidizing agent in the coupled redox.
A crystal structure specifies the chemical species and spatial arrangement of the chemical atoms or ions in a crystal. For an ideal periodic structure, separate two ingredients: a Bravais lattice specifies the translations that repeat the arrangement, and an atomic basis of a crystal specifies the chemical motif repeated at every lattice point. The outward shape, or crystal habit, is a different description: the internal arrangement is what this article describes.
Pinned article: Introduction to the OurBigBook Project
Welcome to the OurBigBook Project! Our goal is to create the perfect publishing platform for STEM subjects, and get university-level students to write the best free STEM tutorials ever.
Everyone is welcome to create an account and play with the site: ourbigbook.com/go/register. We belive that students themselves can write amazing tutorials, but teachers are welcome too. You can write about anything you want, it doesn't have to be STEM or even educational. Silly test content is very welcome and you won't be penalized in any way. Just keep it legal!
Intro to OurBigBook
. Source. We have two killer features:
- topics: topics group articles by different users with the same title, e.g. here is the topic for the "Fundamental Theorem of Calculus" ourbigbook.com/go/topic/fundamental-theorem-of-calculusArticles of different users are sorted by upvote within each article page. This feature is a bit like:
- a Wikipedia where each user can have their own version of each article
- a Q&A website like Stack Overflow, where multiple people can give their views on a given topic, and the best ones are sorted by upvote. Except you don't need to wait for someone to ask first, and any topic goes, no matter how narrow or broad
This feature makes it possible for readers to find better explanations of any topic created by other writers. And it allows writers to create an explanation in a place that readers might actually find it.Figure 1. Screenshot of the "Derivative" topic page. View it live at: ourbigbook.com/go/topic/derivativeVideo 2. OurBigBook Web topics demo. Source. - local editing: you can store all your personal knowledge base content locally in a plaintext markup format that can be edited locally and published either:This way you can be sure that even if OurBigBook.com were to go down one day (which we have no plans to do as it is quite cheap to host!), your content will still be perfectly readable as a static site.
- to OurBigBook.com to get awesome multi-user features like topics and likes
- as HTML files to a static website, which you can host yourself for free on many external providers like GitHub Pages, and remain in full control
Figure 2. You can publish local OurBigBook lightweight markup files to either OurBigBook.com or as a static website.Figure 3. Visual Studio Code extension installation.Figure 5. . You can also edit articles on the Web editor without installing anything locally. Video 3. Edit locally and publish demo. Source. This shows editing OurBigBook Markup and publishing it using the Visual Studio Code extension. - Infinitely deep tables of contents:
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