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Researcher in craniofacial development. With Richard A. Schneider, Helms investigated the cellular and molecular origins of beak form, connecting developmental interactions with differences in anatomical shape.[ref]
The cellular and molecular origins of beak morphology by Richard A. Schneider and Jill A. Helms. Title, author list and reported study
Researcher in evolutionary developmental biology. Abitua and collaborators investigated a neural-crest rudiment in a nonvertebrate chordate, testing how components of a vertebrate developmental program relate to earlier chordate traits.[ref]
Researcher in DNA replication. Remus and collaborators studied loading of Mcm2–7 double hexamers during origin licensing, connecting the assembly of a molecular complex with preparation for genome duplication.[ref]
Researcher in cell cycle control. With Paul Nurse, Coudreuse tested how a minimal cyclin-dependent-kinase network can drive the cell cycle, using simplification to identify which regulatory features are sufficient.[ref]
Driving the cell cycle with a minimal CDK control network by Damien Coudreuse and Paul Nurse. Title, author list and reported study
Geneticist studying the cell cycle. Paul Nurse and collaborators used fission-yeast mutants to identify genetic controls of division, establishing an experimental route from a cell-cycle phenotype to its molecular regulators.[ref]
Portrait of Paul Nurse
. Photographer not specified in the submission; submitted by Ryoko Mandeville on behalf of Paul Nurse. CC BY-SA 3.0, via Wikimedia Commons. Source.Researcher in the tumour microenvironment. Orimo and collaborators investigated how stromal fibroblasts from invasive breast carcinomas promote growth and angiogenesis, connecting local secreted signals with tumor support.[ref]
Researcher in tumor-cell migration. Wyckoff and collaborators studied a signaling loop between macrophages and tumor cells in mammary tumours, connecting interactions between cell types with invasive behavior.[ref]
Researcher in metastasis. Hoshino and collaborators investigated how tumor-exosome integrins contribute to organ-specific dissemination, connecting signals carried by extracellular vesicles with the sites of later tumor growth.[ref]
Tumour exosome integrins determine organotropic metastasis by Ayuko Hoshino and others. Title, author list and reported study
Researcher in tumor metabolism. Sousa and collaborators investigated alanine secretion by pancreatic stellate cells, connecting autophagy in surrounding cells with nutrient support for tumour growth.[ref]
Researcher in the tumour microenvironment. Özdemir and collaborators investigated how depleting carcinoma-associated fibroblasts can accelerate pancreatic cancer in a model, showing that stromal cells can have context-dependent protective functions.[ref]
Researcher in chromosome segregation. Uhlmann and collaborators showed that cleavage of the cohesin subunit Scc1 promotes sister-chromatid separation, connecting a specific proteolytic event with the onset of anaphase.[ref]
Portrait of Frank Uhlmann
. The Royal Society. CC BY-SA 3.0, via Wikimedia Commons. Source.Researcher in cytokinesis. Yüce and collaborators studied how an ECT2–centralspindlin complex regulates RhoA localization and activity, connecting spindle-associated signals with placement of the contractile apparatus.[ref]
Researcher in cell division. Steigemann and collaborators investigated an Aurora-B-dependent abscission checkpoint that protects against tetraploidy, connecting chromosome segregation with completion of cellular separation.[ref]
Researcher in DNA replication. Yeeles and collaborators reconstructed regulated replication-origin firing with purified proteins, using controlled reconstitution to identify the machinery sufficient for this step.[ref]
Researcher in DNA replication. Graham and collaborators examined independent and stochastic behavior of DNA polymerases within the replisome, connecting molecular fluctuations with the coordinated duplication of a genome.[ref]
Independent and stochastic action of DNA polymerases in the replisome by James E. Graham and others. Title, author list and reported study
Researcher in cancer genomics. Sanchez-Vega and collaborators analyzed oncogenic signaling pathways in The Cancer Genome Atlas, connecting alterations in individual genes with recurrent changes in cellular signaling systems.[ref]
Oncogenic signaling pathways in The Cancer Genome Atlas by Francisco Sanchez-Vega and others. Title, author list and reported study
Researcher in somatic evolution. Martincorena and collaborators compared patterns of natural selection in cancer and other somatic tissues, using genomic variation to distinguish mutation accumulation from selective expansion.[ref]
Universal patterns of selection in cancer and somatic tissues by Iñigo Martincorena and others. Title, author list and reported study
Researcher studying targeted cancer therapies. Prahallad and collaborators investigated feedback activation of EGFR during BRAF inhibition in colon cancer, connecting pathway adaptation with an inadequate drug response.[ref]
Pinned article: Introduction to the OurBigBook Project
Welcome to the OurBigBook Project! Our goal is to create the perfect publishing platform for STEM subjects, and get university-level students to write the best free STEM tutorials ever.
Everyone is welcome to create an account and play with the site: ourbigbook.com/go/register. We belive that students themselves can write amazing tutorials, but teachers are welcome too. You can write about anything you want, it doesn't have to be STEM or even educational. Silly test content is very welcome and you won't be penalized in any way. Just keep it legal!
Intro to OurBigBook
. Source. We have two killer features:
- topics: topics group articles by different users with the same title, e.g. here is the topic for the "Fundamental Theorem of Calculus" ourbigbook.com/go/topic/fundamental-theorem-of-calculusArticles of different users are sorted by upvote within each article page. This feature is a bit like:
- a Wikipedia where each user can have their own version of each article
- a Q&A website like Stack Overflow, where multiple people can give their views on a given topic, and the best ones are sorted by upvote. Except you don't need to wait for someone to ask first, and any topic goes, no matter how narrow or broad
This feature makes it possible for readers to find better explanations of any topic created by other writers. And it allows writers to create an explanation in a place that readers might actually find it.
Figure 1. Screenshot of the "Derivative" topic page. View it live at: ourbigbook.com/go/topic/derivativeVideo 2. OurBigBook Web topics demo. Source. - local editing: you can store all your personal knowledge base content locally in a plaintext markup format that can be edited locally and published either:This way you can be sure that even if OurBigBook.com were to go down one day (which we have no plans to do as it is quite cheap to host!), your content will still be perfectly readable as a static site.
- to OurBigBook.com to get awesome multi-user features like topics and likes
- as HTML files to a static website, which you can host yourself for free on many external providers like GitHub Pages, and remain in full control
Figure 2. You can publish local OurBigBook lightweight markup files to either OurBigBook.com or as a static website.
Figure 3. Visual Studio Code extension installation.
Figure 5. . You can also edit articles on the Web editor without installing anything locally. Video 3. Edit locally and publish demo. Source. This shows editing OurBigBook Markup and publishing it using the Visual Studio Code extension. 
- Infinitely deep tables of contents:
All our software is open source and hosted at: github.com/ourbigbook/ourbigbook
Further documentation can be found at: docs.ourbigbook.com
Feel free to reach our to us for any help or suggestions: docs.ourbigbook.com/#contact