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Researcher in antibody engineering. McCafferty and collaborators displayed antibody variable domains on filamentous bacteriophages, connecting a binding phenotype with an experimentally recoverable genetic sequence.[ref]
Researcher in enzyme engineering. Chen and collaborators used repeated random mutation to tune subtilisin activity in dimethylformamide, testing how directed evolution can adapt an enzyme to an unusual chemical environment.[ref]
Researcher in cell cycle control. Lohka and collaborators purified maturation-promoting factor, connecting a transferable activity that triggers early mitotic events with a biochemically isolatable cellular regulator.[ref]
Researcher in evolution and genome organization. Irwin and collaborators investigated whether viral proteins contributed to histone depletion in dinoflagellates, testing a possible evolutionary explanation for unusual chromosome packaging.[ref]
Researcher in structural biology. Unwin imaged the nicotinic acetylcholine receptor channel in an open state, connecting channel architecture with the structural changes underlying ion conduction.[ref]
Acetylcholine receptor channel imaged in the open state by Nigel Unwin. Title, author list and reported study
Researcher in antibody engineering. Jones and collaborators replaced antigen-recognition regions of a human antibody with mouse counterparts, connecting retained binding specificity with the design of humanized antibodies.[ref]
Researcher in transcription. Flanagan and collaborators investigated a mediator required for activated RNA polymerase II transcription in a reconstructed system, helping connect regulatory factors with the transcription machinery.[ref]
Researcher in cancer biology. Rous showed that a chicken sarcoma could be transmitted by an agent separated from the tumor cells, providing an early experimental foundation for studying virus-associated cancers.[ref]
A sarcoma of the fowl transmissible by an agent separable from the tumor cells by Peyton Rous. Title, author list and reported study
Researcher in chromosome evolution. Gornik and collaborators investigated the loss of ordinary nucleosomal DNA chromosome condensation in dinoflagellates and the appearance of a novel nuclear protein, comparing alternative forms of genome packaging.[ref]
Researcher in photosynthesis. Bellafiore and collaborators showed that STN7 kinase is required for state transitions and light adaptation, connecting a chloroplast kinase with redistribution of excitation between photosystems.[ref]
Researcher in bacterial gene regulation. Waldminghaus and collaborators investigated the FourU RNA thermometer in Salmonella, linking temperature-dependent RNA structure with control of gene expression.[ref]
FourU: a novel type of RNA thermometer in Salmonella by Torsten Waldminghaus and others. Title, author list and reported study
Researcher in RNA regulation. Winkler and collaborators showed that thiamine derivatives can bind directly to messenger RNA and control bacterial gene expression, providing evidence for a metabolite-sensing riboswitch.[ref]
Researcher in metabolic regulation. Stalmans and collaborators examined the sequential inhibition of glycogen phosphorylase and activation of glycogen synthase after glucose administration, connecting reciprocal enzyme control with glycogen storage.[ref]
Author of research on interaction sites between CheA and bacterial chemoreceptors. The study connects molecular contacts with the transfer of information in chemotaxis; the initials are retained to avoid assigning an unverified full identity.[ref]
CheA-Receptor Interaction Sites in Bacterial Chemotaxis by X. Wang and others. Title, author list and reported study
Researcher in photosynthesis. Munekage and collaborators investigated PGR5 in cyclic electron flow around photosystem I and its role in photoprotection, linking electron routing with tolerance of excess light.[ref]
Pinned article: Introduction to the OurBigBook Project
Welcome to the OurBigBook Project! Our goal is to create the perfect publishing platform for STEM subjects, and get university-level students to write the best free STEM tutorials ever.
Everyone is welcome to create an account and play with the site: ourbigbook.com/go/register. We belive that students themselves can write amazing tutorials, but teachers are welcome too. You can write about anything you want, it doesn't have to be STEM or even educational. Silly test content is very welcome and you won't be penalized in any way. Just keep it legal!
Intro to OurBigBook
. Source. We have two killer features:
- topics: topics group articles by different users with the same title, e.g. here is the topic for the "Fundamental Theorem of Calculus" ourbigbook.com/go/topic/fundamental-theorem-of-calculusArticles of different users are sorted by upvote within each article page. This feature is a bit like:
- a Wikipedia where each user can have their own version of each article
- a Q&A website like Stack Overflow, where multiple people can give their views on a given topic, and the best ones are sorted by upvote. Except you don't need to wait for someone to ask first, and any topic goes, no matter how narrow or broad
This feature makes it possible for readers to find better explanations of any topic created by other writers. And it allows writers to create an explanation in a place that readers might actually find it.
Figure 1. Screenshot of the "Derivative" topic page. View it live at: ourbigbook.com/go/topic/derivativeVideo 2. OurBigBook Web topics demo. Source. - local editing: you can store all your personal knowledge base content locally in a plaintext markup format that can be edited locally and published either:This way you can be sure that even if OurBigBook.com were to go down one day (which we have no plans to do as it is quite cheap to host!), your content will still be perfectly readable as a static site.
- to OurBigBook.com to get awesome multi-user features like topics and likes
- as HTML files to a static website, which you can host yourself for free on many external providers like GitHub Pages, and remain in full control
Figure 2. You can publish local OurBigBook lightweight markup files to either OurBigBook.com or as a static website.
Figure 3. Visual Studio Code extension installation.
Figure 5. . You can also edit articles on the Web editor without installing anything locally. Video 3. Edit locally and publish demo. Source. This shows editing OurBigBook Markup and publishing it using the Visual Studio Code extension. 
- Infinitely deep tables of contents:
All our software is open source and hosted at: github.com/ourbigbook/ourbigbook
Further documentation can be found at: docs.ourbigbook.com
Feel free to reach our to us for any help or suggestions: docs.ourbigbook.com/#contact