Topics (384k) Articles (398k) Users (410) Discussions (242) Comments (383) Files (13k) New article
Researcher studying past environments and animal history. Gonzalez and collaborators investigated evidence that the Irish elk survived into the Holocene, showing why direct dating can change an inferred extinction chronology.[ref]
Survival of the Irish elk into the Holocene by Silvia Gonzalez and others. Title, author list and reported study
Researcher studying past animal populations. Baker and collaborators investigated the long history of fallow deer and human influence on their distribution, connecting historical evidence with modern conservation biology.[ref]
Researcher in chromatin biology and bioinformatics. With Jorja G. Henikoff, Henikoff developed amino acid substitution matrices from conserved protein blocks; these provide empirically grounded scores for comparing protein sequences.[ref]
Amino acid substitution matrices from protein blocks by Steven Henikoff and Jorja G. Henikoff. Title, author list and reported study
Researcher in bioinformatics who, with Steven Henikoff, developed amino acid substitution matrices from conserved protein blocks. These matrices turn observed replacement patterns into scores for protein sequence alignment.[ref]
Amino acid substitution matrices from protein blocks by Steven Henikoff and Jorja G. Henikoff. Title, author list and reported study
Researcher in bioinformatics. With David J. Lipman, Pearson developed tools for biological sequence comparison that became associated with FASTA, making similarity searches practical for growing sequence collections.[ref]
Improved tools for biological sequence comparison by William R. Pearson and David J. Lipman. Title, author list and reported study
Researcher in bioinformatics. With William R. Pearson, Lipman developed improved tools for biological sequence alignment, connecting computational search methods with the comparison of biological sequences.[ref]
Improved tools for biological sequence comparison by William R. Pearson and David J. Lipman. Title, author list and reported study
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Portrait of David J. Lipman
. Brian Glanz / Open Science Federation; White House Open Science Champions of Change (2013); existing Commons crop. CC BY 2.0, via Wikimedia Commons. Source.Researcher in genome engineering. Cong and collaborators demonstrated multiplex targeting using CRISPR-Cas9 systems, helping establish a programmable way to alter more than one genomic site in an experiment.[ref]
Multiplex genome engineering using CRISPR/Cas systems by Le Cong and others. Title, author list and reported study
Researcher in gene regulation. Gilbert and collaborators developed modular RNA-guided regulation of transcription using CRISPR-Cas9, showing how sequence-directed targeting can control gene activity rather than only cut DNA.[ref]
Researcher in molecular diagnostics. Saiki and collaborators used enzymatic amplification of beta-globin sequences and restriction-site analysis to investigate sickle cell disease, helping establish the practical usefulness of polymerase chain reaction.[ref]
Researcher in structural biology. Kawashima and collaborators determined the structure of the EF-Tu–EF-Ts complex, connecting interactions between translation factors with the molecular mechanism of nucleotide exchange.[ref]
Researcher in protein crystallography. Wright and collaborators determined the structure of subtilisin BPN′ at 2.5 Å resolution, making the spatial organization of a proteolytic enzyme accessible to mechanistic interpretation.[ref]
Structure of Subtilisin BPN′ at 2.5 Å Resolution by C. S. Wright and others. Title, author list and reported study
Researcher in catalytic antibodies. Tramontano and collaborators investigated whether the molecular recognition of an antibody can be used to accelerate a chemical reaction, connecting selective binding with catalysis.[ref]
Researcher studying insulin and glucose transport. Cushman and collaborators investigated the movement of intracellular transport systems to the cell membrane in adipose cells, helping distinguish transporter redistribution from production of additional transporter molecules.[ref]
Biochemist who studied energy conversion through reconstituted membrane systems. Racker and collaborators combined light-driven proton transport with ATP formation in vesicles, testing whether the component processes could operate together outside an intact cell.[ref]
Portrait of Efraim Racker
. Staff Asbmb. CC BY 2.0, via Wikimedia Commons. Source.Researcher in photosynthesis. Jagendorf and collaborators showed ATP formation after an imposed acid–base transition in isolated chloroplasts, making a transmembrane proton difference experimentally separable from the ordinary light-driven process.[ref]
ATP formation caused by acid-base transition of spinach chloroplasts by A. T. Jagendorf and others. Title, author list and reported study
Researcher studying bacterial toxins and cellular signaling. D. M. Gill and collaborators investigated how cholera toxin catalyzes ADP-ribosylation of membrane proteins and activates adenylyl cyclase, connecting a chemical modification with toxin action.[ref]
Pinned article: Introduction to the OurBigBook Project
Welcome to the OurBigBook Project! Our goal is to create the perfect publishing platform for STEM subjects, and get university-level students to write the best free STEM tutorials ever.
Everyone is welcome to create an account and play with the site: ourbigbook.com/go/register. We belive that students themselves can write amazing tutorials, but teachers are welcome too. You can write about anything you want, it doesn't have to be STEM or even educational. Silly test content is very welcome and you won't be penalized in any way. Just keep it legal!
Intro to OurBigBook
. Source. We have two killer features:
- topics: topics group articles by different users with the same title, e.g. here is the topic for the "Fundamental Theorem of Calculus" ourbigbook.com/go/topic/fundamental-theorem-of-calculusArticles of different users are sorted by upvote within each article page. This feature is a bit like:
- a Wikipedia where each user can have their own version of each article
- a Q&A website like Stack Overflow, where multiple people can give their views on a given topic, and the best ones are sorted by upvote. Except you don't need to wait for someone to ask first, and any topic goes, no matter how narrow or broad
This feature makes it possible for readers to find better explanations of any topic created by other writers. And it allows writers to create an explanation in a place that readers might actually find it.
Figure 1. Screenshot of the "Derivative" topic page. View it live at: ourbigbook.com/go/topic/derivativeVideo 2. OurBigBook Web topics demo. Source. - local editing: you can store all your personal knowledge base content locally in a plaintext markup format that can be edited locally and published either:This way you can be sure that even if OurBigBook.com were to go down one day (which we have no plans to do as it is quite cheap to host!), your content will still be perfectly readable as a static site.
- to OurBigBook.com to get awesome multi-user features like topics and likes
- as HTML files to a static website, which you can host yourself for free on many external providers like GitHub Pages, and remain in full control
Figure 2. You can publish local OurBigBook lightweight markup files to either OurBigBook.com or as a static website.
Figure 3. Visual Studio Code extension installation.
Figure 5. . You can also edit articles on the Web editor without installing anything locally. Video 3. Edit locally and publish demo. Source. This shows editing OurBigBook Markup and publishing it using the Visual Studio Code extension. 
- Infinitely deep tables of contents:
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All our software is open source and hosted at: github.com/ourbigbook/ourbigbook
Further documentation can be found at: docs.ourbigbook.com
Feel free to reach our to us for any help or suggestions: docs.ourbigbook.com/#contact