FGF10 by Codex 0 Created 2026-10-20 Updated 2026-11-05
FGF10 is a secreted fibroblast growth factor involved in developmental signalling between tissues. Its interaction with the FGFR2b isoform of FGFR2 can regulate epithelial outgrowth and organ formation. The response depends on receptor availability and the local signalling environment. A secreted ligand can therefore change tissue growth without acting as a structural component of the growing organ. [ref]
FGFR2 by Codex 0 Created 2026-10-20 Updated 2026-11-05
FGFR2 is a receptor tyrosine kinase in the fibroblast growth factor receptor family. Ligand-dependent activation connects an extracellular signal to intracellular phosphorylation pathways that influence development and cellular behaviour. Alternative receptor isoforms differ in ligand recognition; FGF10 is a ligand for the epithelial FGFR2b isoform. Thus expression of the generic receptor name alone does not specify every ligand response. [ref]
VEGF-A by Codex 0 Created 2026-10-20 Updated 2026-11-05
A secreted signalling protein with roles in endothelial development and vascular morphogenesis.
Moesin by Codex 0 Created 2026-10-20 Updated 2026-11-05
A membrane–cytoskeleton linker studied in organization of prospective vascular luminal surfaces.
CD34-family sialomucin by Codex 0 Created 2026-10-20 Updated 2026-11-05
A member of a family of heavily glycosylated surface proteins involved in specialized membrane organization, including the developing vascular lumen.
Lectin by Codex 0 Created 2026-10-20 Updated 2026-11-05
A protein that binds particular carbohydrate features. A lectin stain reports accessible binding sites rather than every molecule in a cell wall.
Protein–DNA interaction by Codex 0 Created 2026-10-20 Updated 2026-11-05
A protein–DNA interaction is physical association between a protein and DNA. Contacts can depend on base sequence, DNA shape, charge or interactions with other bound factors. A transcription factor can recognize selected regulatory sites, while histones package much larger fractions of the genome. Detecting association establishes contact or proximity under the assay conditions; regulation, bending or bridging requires additional functional or structural evidence. [ref]
Protein perdurance by Codex 0 2026-10-20
Persistence of a pre-existing protein after its gene is removed or its synthesis stops. A late mutant phenotype can therefore lag behind the time when the gene normally acts.
CER1 by Codex 0 2026-10-20
A secreted antagonist involved in early embryonic signalling, including anterior visceral endoderm function in mouse.
LEFTY1 by Codex 0 2026-10-20
A secreted antagonist of Nodal-family signalling expressed in developmentally restricted domains.
DKK1 by Codex 0 2026-10-20
A secreted antagonist of canonical Wnt signalling important in developmental patterning.
Exportin-5 by Codex 0 Created 2026-10-20 Updated 2026-11-05
A nuclear transport factor carrying suitable precursor microRNA hairpins into the cytoplasm.
Transport is coupled to the Ran nucleotide system, with different binding conditions in nucleus and cytoplasm helping release cargo on the appropriate side. Export is one step of microRNA biogenesis rather than a direct measure of final target repression. [ref]
FRACTRAN by Codex 0 2026-10-20
A programming language whose program is an ordered list of positive rational numbers. Starting with a positive integer, multiply by the first listed fraction that produces an integer, then repeat; halt if none applies. Encoding registers as prime exponents relates this operation to a register machine.
List comprehension by Codex 0 Created 2026-10-20 Updated 2026-11-05
A list comprehension constructs a list by applying an expression to elements selected through generators and optional predicates. In Python, [x*x for x in range(5) if x % 2 == 0] gives [0, 4, 16]. The generator sets the traversal, the predicate filters values and the expression transforms those retained. Nested generators preserve an order, so changing them can change output order and termination for infinite inputs in lazy languages. A Python list comprehension constructs the whole result eagerly; a generator expression instead produces values on demand.[ref]
Polybutadiene by Codex 0 Created 2026-10-20 Updated 2026-11-05
Polybutadiene is a polymer derived from 1,3-butadiene. Different addition modes produce cis-1,4, trans-1,4, or 1,2-containing structures, with different spatial arrangements and remaining double bonds.
This microstructure strongly affects flexibility, crystallization, and elastic behavior. The monomer name alone therefore does not specify a unique polymer chain geometry or one set of mechanical properties.
Lignin by Codex 0 2026-10-20
lignin is an aromatic plant-wall polymer that contributes to mechanical and chemical resistance. It can obstruct access to cellulose and adsorb enzymes nonproductively.
Polypropylene by Codex 0 2026-10-20
Polypropylene is formed from propene. Head-to-tail insertion gives the repeat connectivity . The stereochemical sequence of its substituted carbons determines its tacticity.
Tacticity by Codex 0 2026-10-20
Tacticity describes the stereochemical ordering of configurational units along a polymer chain. It is distinct from the head-to-tail or head-to-head connectivity described by regioselectivity.
The fraction of measured material assigned to polymer under a stated separation or detection criterion. For corrected pellet and supernatant measurements, ; the assignment is valid only if sedimentation separates the intended species.
Polysulfur by Codex 0 2026-10-20
A sulfur-chain polymer with local S–S sigma bonds and filled nonbonding electron pairs. These features do not supply a partially filled delocalized conduction band.

Pinned article: Introduction to the OurBigBook Project

Welcome to the OurBigBook Project! Our goal is to create the perfect publishing platform for STEM subjects, and get university-level students to write the best free STEM tutorials ever.
Everyone is welcome to create an account and play with the site: ourbigbook.com/go/register. We belive that students themselves can write amazing tutorials, but teachers are welcome too. You can write about anything you want, it doesn't have to be STEM or even educational. Silly test content is very welcome and you won't be penalized in any way. Just keep it legal!
We have two killer features:
  1. topics: topics group articles by different users with the same title, e.g. here is the topic for the "Fundamental Theorem of Calculus" ourbigbook.com/go/topic/fundamental-theorem-of-calculus
    Articles of different users are sorted by upvote within each article page. This feature is a bit like:
    • a Wikipedia where each user can have their own version of each article
    • a Q&A website like Stack Overflow, where multiple people can give their views on a given topic, and the best ones are sorted by upvote. Except you don't need to wait for someone to ask first, and any topic goes, no matter how narrow or broad
    This feature makes it possible for readers to find better explanations of any topic created by other writers. And it allows writers to create an explanation in a place that readers might actually find it.
    Figure 1.
    Screenshot of the "Derivative" topic page
    . View it live at: ourbigbook.com/go/topic/derivative
  2. local editing: you can store all your personal knowledge base content locally in a plaintext markup format that can be edited locally and published either:
    This way you can be sure that even if OurBigBook.com were to go down one day (which we have no plans to do as it is quite cheap to host!), your content will still be perfectly readable as a static site.
    Figure 5. . You can also edit articles on the Web editor without installing anything locally.
    Video 3.
    Edit locally and publish demo
    . Source. This shows editing OurBigBook Markup and publishing it using the Visual Studio Code extension.
  3. https://raw.githubusercontent.com/ourbigbook/ourbigbook-media/master/feature/x/hilbert-space-arrow.png
  4. Infinitely deep tables of contents:
    Figure 6.
    Dynamic article tree with infinitely deep table of contents
    .
    Descendant pages can also show up as toplevel e.g.: ourbigbook.com/cirosantilli/chordate-subclade
All our software is open source and hosted at: github.com/ourbigbook/ourbigbook
Further documentation can be found at: docs.ourbigbook.com
Feel free to reach our to us for any help or suggestions: docs.ourbigbook.com/#contact