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A confidence interval is a random interval constructed from a statistical sample to cover a fixed unknown statistical parameter with a prescribed coverage probability. For a scalar target $\theta$, a procedure with nominal confidence $1-\alpha$ satisfiesThe subscript records which probability distribution generates the repeated samples. The endpoints are statistics, so they vary from sample to sample; the target is fixed. Equality gives exact nominal coverage probability, while the inequality also permits conservative procedures. For a general estimand $\psi (\theta )$, replace the target inside the interval by $\psi (\theta )$.

A realized confidence interval communicates the precision of an estimate in the target's own units. Reporting $1.2$ alone conceals the difference between an estimate with standard error $0.5$ and one with standard error $0.05$. A narrow confidence interval indicates greater precision for the stated statistical model, rather than a guarantee that its assumptions describe the experiment correctly.

Once $x$ is observed, $C(x)$ either contains the fixed target or does not. The 95% statement concerns the random procedure $C(X)$, not a posterior probability of 0.95 that this particular interval contains $\theta$. A credible interval instead assigns specified posterior probability to a region under Bayesian inference. These interpretations can differ even when the numerical endpoints agree. The repeated-sampling interpretation is explained in NIST's confidence-limits teaching reference.

Jerzy Neyman's 1937 paper formulates the fixed-target, random-endpoint construction in Section II, especially equation (20) on page 348. Its confidence coefficient must hold across the allowed statistical parameters, rather than only at the value suggested by one sample. See Neyman, Outline of a Theory of Statistical Estimation Based on the Classical Theory of Probability and the original paper scan.

Statistical efficiency compares the precision of procedures estimating the same estimand. For unbiased estimators, relative efficiency is commonly a ratio of their variances; lower variance means more information from the same sample size. An efficient estimator attains a relevant information lower bound. A baseline-adjusted linear regression can improve precision in a randomized controlled trial by removing prognostic variation.

The jackknife bias correction uses jackknife resampling to estimate and subtract the bias of an estimator. Here $T_n$ denotes the original estimator, $T_{(-i)}$ its version after deleting observation $i$, and ${\overline{T}}_J=n^{-1}{\sum }_{i=1}^n{T}_{(-i)}$ the mean of those versions. For sample size $n>1$, defineThe sign matters: a negative estimated bias increases the corrected value. The original estimator and all deletion versions must target the same estimand and use the same estimation rule at their respective sample sizes. The definition alone does not make ${\tilde{T}}_J$ an unbiased estimator.

For an exact worked example, take the empirical varianceOn $(1,2,3,4,10)$, the sample mean is $4$ and $T_5=50/5=10$. Each deletion empirical variance is recomputed around its own deletion sample mean, with divisor $4$, givingFor instance, deleting $10$ leaves $(1,2,3,4)$, whose sample mean is $2.5$ and whose empirical variance is $1.25$. The correction on the full statistical sample isThe same data thus give a jackknife variance estimator of $2.5$ for the sample mean, and a corrected empirical variance of $12.5$; these are different estimands.

The exact equality with the usual sample variance is not an accident of these numbers. For any data with $n>1$, write $Q={\sum }_i(x_i-\overline{x}{)}^2=n{T}_n$. Removing $x_i$ changes this sum to $Q-n(x_i-\overline{x}{)}^2/(n-1)$, soFor independent and identically distributed random variables with finite second moment and population variance ${\sigma }^2$, the expectation is $\mathbb{E}{T}_n=(1-1/n){\sigma }^2$. Its bias is exactly $-{\sigma }^2/n$; jackknife bias correction removes it exactly in this example. Thus $s_n^2$ is an unbiased estimator of ${\sigma }^2$ under these assumptions, including $n=2$ where each deletion empirical variance is zero.

More generally, suppose the bias has a regular expansion at both sample sizes $n$ and $n-1$, with coefficients $a,b$ independent of $n$:Under independent and identically distributed sampling, each deletion estimator has the same expectation as $T_{n-1}$. Hence the corrected bias isThe leading $O(n^{-1})$ term cancels; the remaining bias need not vanish. The $O$ notation is big O notation. This argument presumes the expansion, rather than proving it for every statistic; the regularity conditions discussed for the jackknife variance estimator and statistical dependence still require care. Shalizi's ^[ref] develop the cancellation argument and cite Quenouille's ^[ref].

The delete-one form of jackknife resampling recalculates a statistic after deleting each observation in turn. It uses one observed statistical sample to investigate how sensitive an estimator is to its individual observations, and supplies both a jackknife variance estimator and jackknife bias correction. The calculations are deterministic once the data are fixed: no random draws are needed.

In the basic setting, $X_1,\dots ,X_n$ are independent and identically distributed random variables, with sample size $n>1$. Let $x_1,\dots ,x_n$ be the observed values and ${\hat{\theta }}_n=t_n(x_1,\dots ,x_n)$ a scalar estimator of an estimand $\theta$. Apply the same estimation rule to each reduced statistical sample, using its new sample size $n-1$ wherever the rule requires it:Every index is deleted exactly once; an unusual value is treated by the same rule as every other value. The mean ${\overline{\theta }}_J$ summarizes the deletion estimates. They overlap in $n-2$ observations, so they are generally not independent random variables representing fresh repetitions of the original experiment. Cosma Shalizi's ^[ref] explain this construction and its scaling.

For a concrete sample mean, use the data $(1,2,3,4,10)$, whose full sample mean is $\overline{x}=4$. The five deletion sample means, in observation order, areDeleting $1$ raises the sample mean by $0.75$, while deleting $10$ lowers the sample mean by $1.5$. Thus $10$ has the largest deletion effect in this statistical sample. This is a descriptive sensitivity calculation, not a rule for removing that observation: the full sample mean remains $4$.

Early literature includes M. H. Quenouille's ^[ref] and John W. Tukey's one-paragraph abstract ^[ref], within the issue's collected abstracts. Shalizi's ^[ref] discuss the later development of jackknife bias correction and the jackknife variance estimator.

A treatment consequence is not interchangeable with a baseline covariate in an intention-to-treat analysis. Let randomized $Z$ be independent of $U,\epsilon$, and let actual intervention use be $D=Z+U$, with $Y=D+\epsilon$ and independent centered errors. The assignment changes the mean outcome by one. But the conditional expectation $\mathbb{E}[Y\mid Z,D]=D$ has coefficient zero on $Z$. Thus adjustment for the post-randomization variable $D$ changes the estimand even in a simple identified linear regression.

Here simple random sampling means a random unordered subset $A$ of exactly $n$ distinct labels from $\{1,\dots ,N\}$, with every size-$n$ subset equally likely. The sample size is fixed in advance, $1\le n\le N$, and sampling without replacement prevents duplicate units. This is SRSWOR; some texts also use "simple random sampling" for independent uniform draws with replacement, which is a different design.^[ref]

Every label has inclusion probability $n/N$, but equal inclusion probabilities alone are insufficient. For example, from six labels choose either $\{1,2,3\}$ or $\{4,5,6\}$ with probability $1/2$. Each label is included with probability $1/2$, yet eighteen of the twenty size-three subsets are impossible: this is a two-group cluster sampling design. Unequal probability sampling deliberately changes inclusion probabilities, often to improve precision for a particular estimand, and generally requires an appropriately weighted estimator rather than the plain sample mean.

Consider the original mathematical population with labelled values $(2,4,6,8,10,12)$, and let $n=2$. The fifteen equiprobable subsets, followed by their sample means, areTheir sample means sum to $105$, giving expected value $105/15=7$. Their squared deviations from $7$ sum to $70$, giving variance $70/15=14/3$. This is an enumeration over hypothetical selections from six stipulated numbers, not measured survey data.

With independent uniform sampling with replacement, the $6^2=36$ ordered outcomes each have probability $1/36$. The two orders $(2,4)$ and $(4,2)$ are distinct outcomes, and $(2,2)$ is now possible. Forgetting order does not make the resulting unordered multisets equiprobable: $\{2,4\}$ has probability $2/36$ but $\{2,2\}$ has probability $1/36$. The thirty-six sample means still have expected value $7$, but their squared deviations sum to $210$, giving variance $210/36=35/6$. Avoiding duplicate labels improves precision for this fixed population.

Statistical inference uses observed data and a statistical model to learn about unknown features of the process that generated them. In a parametric statistical model, write $X\sim P_{\theta }$: the probability distribution depends on an unknown statistical parameter $\theta$. An estimand specifies the target, such as a mean or a difference of means. A statistic is a function of the observations; an estimator is a statistic used to estimate the target. Uppercase $X$ denotes the random data before observation, while lowercase $x$ denotes their realized values.

Three questions lead to different outputs. Statistical estimation asks which target value the observations suggest. A confidence interval asks for a range produced by a procedure with calibrated coverage probability. A hypothesis test asks whether the observations depart sufficiently from a specified null hypothesis to enter its rejection region. These outputs complement one another: an estimated effect size describes magnitude, while a standard error describes the sampling distribution of an estimator. A p-value describes a tail probability under the null hypothesis.

The appeal of statistical inference is that it turns variable observations into reproducible uncertainty statements. In the normal mean confidence interval with known variance below, a sample mean of $1.2$ has standard error $0.5$: both the estimated shift and its precision matter. The calibration depends on the statistical model, including independence and the specified probability distribution. Increasing sample size improves precision under those assumptions; it does not repair a systematically misleading sampling procedure. Bayesian inference provides another framework, using a prior distribution and a likelihood function to obtain a posterior distribution.