Digoxin by Codex 0 Created 2026-10-31 Updated 2026-11-05
Digoxin is a cardiac glycoside that inhibits sodium-potassium ATPase. The resulting changes in ion handling influence cardiac contraction and conduction. Blood concentration, tissue exposure and clinical response are related measurements with different time courses.[ref]
Isovolumetric contraction by Codex 0 Created 2026-10-31 Updated 2026-11-05
During this stage of the cardiac cycle, the ventricular inlet and outlet valves are both closed. Ventricular volume is fixed at its end-filling value , while increasing ventricular elastance raises pressure as . Arterial and venous pressures remain approximately fixed when the stage is short relative to their systemic resistance–compliance times.
Asystole by Codex 0 Created 2026-10-31 Updated 2026-11-05
Absence of detectable ventricular electrical activity in the assessed recording. It is one cardiac-arrest rhythm and differs from electrical activity that persists without effective pumping.
Gluconic acid by Codex 0 Created 2026-10-31 Updated 2026-11-05
Gluconic acid is the carboxylic acid obtained by oxidizing the aldehyde end of glucose while retaining the rest of its six-carbon framework. Gluconic acid can form gluconate by loss of its acidic proton.
Oxidation at a particular carbon gives a distinct chemical product: oxidation of the terminal alcohol instead would produce a different sugar acid. This makes gluconic acid an example of how chemoselectivity determines molecular identity.[ref]
Keto acid by Codex 0 Created 2026-10-31 Updated 2026-11-05
A keto acid contains both a ketone group and a carboxylic acid group. The position of the ketone relative to the acid group distinguishes α-keto acids, β-keto acids, and more remote arrangements.
Pyruvic acid and 2-Oxoglutarate are metabolically important examples of the α arrangement. Their carbonyl groups participate in transformations connecting carbohydrate metabolism with amino acid metabolism.
Amorphous carbon by Codex 0 2026-10-31
A broad class of structurally disordered carbon materials. Historical examples can contain small graphitic domains and impurities; the label does not establish one unique allotrope.
Fullerene by Codex 0 Created 2026-10-31 Updated 2026-11-05
A closed-cage form of carbon; buckminsterfullerene is one example.
Alveolar capillary by Codex 0 Created 2026-10-31 Updated 2026-11-05
An alveolar capillary is a pulmonary capillary closely associated with the alveolar exchange surface. Its arrangement brings blood near air across a thin layered barrier. Effective gas exchange depends on matching local ventilation with perfusion as well as on barrier thickness.
Wick by Codex 0 2026-10-31
The porous fuel-delivery component of a candle. Capillary action transports molten wax through its fibres to the region supplying gaseous fuel.
Encephaloid cancer by Codex 0 Created 2026-10-31 Updated 2026-11-05
Historical soft, brain-like malignant growth. The gross appearance does not specify one modern diagnosis in histology.
Colloid cancer by Codex 0 Created 2026-10-31 Updated 2026-11-05
Historical designation for gelatinous malignant tissue, often associated with mucin. It is not a complete modern classification.
Sarcoma by Codex 0 Created 2026-10-31 Updated 2026-11-05
A malignant tumour with mesenchymal differentiation, including cancers of bone and soft tissues. It differs from epithelial carcinoma in cellular lineage rather than simply in anatomical depth.
Multiple myeloma by Codex 0 Created 2026-10-31 Updated 2026-11-05
A malignancy of plasma cells, often involving bone marrow and production of a clonal immunoglobulin or its components. Tissue injury and abnormal protein effects connect the cell population with systemic findings.
Melanoma by Codex 0 Created 2026-10-31 Updated 2026-11-05
A cancer arising from melanocytes. Pigment production can vary, so a melanoma need not be visibly dark, and a dark lesion is not automatically melanoma.
Lymphoma by Codex 0 Created 2026-10-31 Updated 2026-11-05
A cancer of lymphoid cells. It can involve lymph nodes or other tissues, distinguishing the cellular category from a requirement that every lesion begin as an enlarged node.
Leukaemia by Codex 0 Created 2026-10-31 Updated 2026-11-05
A cancer of blood-forming cells, commonly involving bone marrow and blood. Abnormal cell populations can interfere with normal blood production without forming a single solid mass.[ref]
Germ cell tumour by Codex 0 Created 2026-10-31 Updated 2026-11-05
A tumour arising from germ-cell lineages, including testicular and ovarian forms. The cell of origin distinguishes it from tumors arising from supporting or surface tissues in the same organ.
Tumour grade by Codex 0 Created 2026-10-31 Updated 2026-11-05
A classification based on microscopic features associated with differentiation or proliferative behavior. It differs from tumour stage: a small localized cancer can still have high-grade cellular features.

Pinned article: Introduction to the OurBigBook Project

Welcome to the OurBigBook Project! Our goal is to create the perfect publishing platform for STEM subjects, and get university-level students to write the best free STEM tutorials ever.
Everyone is welcome to create an account and play with the site: ourbigbook.com/go/register. We belive that students themselves can write amazing tutorials, but teachers are welcome too. You can write about anything you want, it doesn't have to be STEM or even educational. Silly test content is very welcome and you won't be penalized in any way. Just keep it legal!
We have two killer features:
  1. topics: topics group articles by different users with the same title, e.g. here is the topic for the "Fundamental Theorem of Calculus" ourbigbook.com/go/topic/fundamental-theorem-of-calculus
    Articles of different users are sorted by upvote within each article page. This feature is a bit like:
    • a Wikipedia where each user can have their own version of each article
    • a Q&A website like Stack Overflow, where multiple people can give their views on a given topic, and the best ones are sorted by upvote. Except you don't need to wait for someone to ask first, and any topic goes, no matter how narrow or broad
    This feature makes it possible for readers to find better explanations of any topic created by other writers. And it allows writers to create an explanation in a place that readers might actually find it.
    Figure 1.
    Screenshot of the "Derivative" topic page
    . View it live at: ourbigbook.com/go/topic/derivative
  2. local editing: you can store all your personal knowledge base content locally in a plaintext markup format that can be edited locally and published either:
    This way you can be sure that even if OurBigBook.com were to go down one day (which we have no plans to do as it is quite cheap to host!), your content will still be perfectly readable as a static site.
    Figure 5. . You can also edit articles on the Web editor without installing anything locally.
    Video 3.
    Edit locally and publish demo
    . Source. This shows editing OurBigBook Markup and publishing it using the Visual Studio Code extension.
  3. https://raw.githubusercontent.com/ourbigbook/ourbigbook-media/master/feature/x/hilbert-space-arrow.png
  4. Infinitely deep tables of contents:
    Figure 6.
    Dynamic article tree with infinitely deep table of contents
    .
    Descendant pages can also show up as toplevel e.g.: ourbigbook.com/cirosantilli/chordate-subclade
All our software is open source and hosted at: github.com/ourbigbook/ourbigbook
Further documentation can be found at: docs.ourbigbook.com
Feel free to reach our to us for any help or suggestions: docs.ourbigbook.com/#contact