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A DNA-binding protein associates physically with DNA. Some recognize selected base patterns, while others preferentially recognize DNA shape, ends or damage. Transcription factors regulate expression, histones organize packaging and repair factors inspect damaged substrates. These roles illustrate why binding alone does not establish a specific regulatory outcome. Sequence selectivity, affinity and cellular occupancy are distinct measurable properties.
Suhas S. P. Rao coauthored research on cohesin.[ref]
Cohesin loss eliminates all loop domains by Suhas S. P. Rao and others. publication title and author list
Cohesin is a multisubunit chromosome-associated protein complex involved in sister-chromatid cohesion and chromosome organization. Cleavage of a cohesin component helps permit sister separation at anaphase. Cohesin also contributes to chromosomal loop organization: acute removal can eliminate loop domains without implying that every aspect of gene expression changes immediately. Its segregation and interphase-organization roles are related but experimentally separable.
A stem cell derived from early embryonic tissue with capacity to generate many differentiated cell types under suitable conditions.
Assembly and positioning of the biological translation machinery at a selected start. ribosome recruitment, scanning and start-codon recognition are distinguishable processes.
Profiling of preserved ribosomal and small-subunit-associated complexes to distinguish stages including scanning and recycling. Captured distributions remain subject to crosslinking and fragment-selection biases.
Andrew J. Aguirre studied how genomic genomic copy number affects CRISPR-Cas9 screening. Targeting amplified genomic regions can produce a response independent of the targeted gene's usual function, an important distinction when interpreting whether a screening signal demonstrates a gene-specific dependency.[ref]
Genomic Copy Number Dictates a Gene-Independent Cell Response to CRISPR/Cas9 Targeting by Andrew J. Aguirre and others. 2016, abstract and copy-number-dependent gene-independent targeting response
Lenny Dang coauthored research on 2-hydroxyglutarate.[ref]
Cancer-associated IDH1 mutations produce 2-hydroxyglutarate by Lenny Dang and others. publication title and author list
A hydroxyglutarate metabolite whose enantiomer and source matter. The R form accumulates after the neomorphic reaction of certain cancer-associated IDH1 mutants.
Erica L. Jackson investigated lung tumour initiation and progression using conditional expression of oncogenic KRAS. Controlling where and when the oncogene is activated makes it possible to separate the triggering event from later changes during tumour development.[ref]
Analysis of lung tumor initiation and progression using conditional expression of oncogenic K-ras by Erica L. Jackson and others. 2001, conditional oncogenic K-ras model and tumour initiation/progression
Robert E. Goldsby investigated the consequences of defective DNA polymerase proofreading in house mouse models. The reported increase in epithelial cancers connected a molecular mechanism for copying fidelity with tumour development in the studied animals.[ref]
High incidence of epithelial cancers in mice deficient for DNA polymerase δ proofreading by Robert E. Goldsby and others. 2002, abstract: DNA polymerase-delta proofreading deficiency and epithelial cancer incidence
Nicoleta Constantin helped reconstitute human DNA mismatch repair from purified components. A strand break on either side of a mismatch could direct correction, showing how strand information and repair proteins cooperate in selecting the sequence to replace.[ref]
Human mismatch repair: reconstitution of a nick-directed bidirectional reaction by Nicoleta Constantin and others. 2005, abstract: seven purified human activities and 3-prime/5-prime nick-directed repair
Repair that recognizes and corrects mismatched sequence after copying or strand exchange. It can also inhibit homologous recombination between sufficiently divergent sequences.
Justin L. Sparks coauthored research on ribonucleotide excision repair.[ref]
RNase H2-initiated ribonucleotide excision repair by Justin L. Sparks and others. publication title and author list
Repair of ribonucleotides embedded in DNA, including molecules with correct base pairing. RNase H2 can initiate an incision followed by replacement synthesis and ligation.
Steven M. Johnson coauthored research on microRNA.[ref]
RAS is regulated by the let-7 microRNA family by Steven M. Johnson and others. publication title and author list
A small regulatory RNA that guides an Argonaute-containing complex to target RNAs, influencing their stability or biological translation.
A small regulatory RNA that guides an Argonaute-containing complex to target RNAs, influencing their stability or biological translation.
Pinned article: Introduction to the OurBigBook Project
Welcome to the OurBigBook Project! Our goal is to create the perfect publishing platform for STEM subjects, and get university-level students to write the best free STEM tutorials ever.
Everyone is welcome to create an account and play with the site: ourbigbook.com/go/register. We belive that students themselves can write amazing tutorials, but teachers are welcome too. You can write about anything you want, it doesn't have to be STEM or even educational. Silly test content is very welcome and you won't be penalized in any way. Just keep it legal!
Intro to OurBigBook
. Source. We have two killer features:
- topics: topics group articles by different users with the same title, e.g. here is the topic for the "Fundamental Theorem of Calculus" ourbigbook.com/go/topic/fundamental-theorem-of-calculusArticles of different users are sorted by upvote within each article page. This feature is a bit like:
- a Wikipedia where each user can have their own version of each article
- a Q&A website like Stack Overflow, where multiple people can give their views on a given topic, and the best ones are sorted by upvote. Except you don't need to wait for someone to ask first, and any topic goes, no matter how narrow or broad
This feature makes it possible for readers to find better explanations of any topic created by other writers. And it allows writers to create an explanation in a place that readers might actually find it.
Figure 1. Screenshot of the "Derivative" topic page. View it live at: ourbigbook.com/go/topic/derivativeVideo 2. OurBigBook Web topics demo. Source. - local editing: you can store all your personal knowledge base content locally in a plaintext markup format that can be edited locally and published either:This way you can be sure that even if OurBigBook.com were to go down one day (which we have no plans to do as it is quite cheap to host!), your content will still be perfectly readable as a static site.
- to OurBigBook.com to get awesome multi-user features like topics and likes
- as HTML files to a static website, which you can host yourself for free on many external providers like GitHub Pages, and remain in full control
Figure 2. You can publish local OurBigBook lightweight markup files to either OurBigBook.com or as a static website.
Figure 3. Visual Studio Code extension installation.
Figure 5. . You can also edit articles on the Web editor without installing anything locally. Video 3. Edit locally and publish demo. Source. This shows editing OurBigBook Markup and publishing it using the Visual Studio Code extension. 
- Infinitely deep tables of contents:
All our software is open source and hosted at: github.com/ourbigbook/ourbigbook
Further documentation can be found at: docs.ourbigbook.com
Feel free to reach our to us for any help or suggestions: docs.ourbigbook.com/#contact