Topics (384k) Articles (398k) Users (410) Discussions (242) Comments (383) Files (13k) New article
Researcher in membrane biophysics. With Sarah L. Keller, Veatch investigated liquid-phase separation in giant vesicles, connecting observable membrane domains with physical interactions among lipids.[ref]
Researcher in membrane biophysics. With Sarah L. Veatch, Keller studied liquid-phase separation in vesicles containing phospholipids and cholesterol, connecting composition with coexistence of distinct membrane regions.[ref]
Researcher in membrane biophysics. Lorent and collaborators investigated differences between the two sides of plasma membranes in lipid unsaturation, packing and protein shape, connecting leaflet asymmetry with molecular organization.[ref]
Researcher in cellular signaling. Irannejad and collaborators used conformational biosensors to investigate GPCR signaling from endosomes, connecting receptor activity with an intracellular location after internalization.[ref]
Conformational biosensors reveal GPCR signalling from endosomes by Roshanak Irannejad and others. Author list and described study
Researcher in tumor biophysics. Stylianopoulos and collaborators investigated growth-induced solid stress in tumors, connecting mechanical compression with changes in the tissue environment and possible ways to relieve that stress.[ref]
Researcher in human evolution. Hershkovitz and collaborators investigated fossil evidence for early modern humans outside Africa, connecting anatomical identification with the chronology of dispersal.[ref]
The earliest modern humans outside Africa by Israel Hershkovitz and others. Author list and described study
Researcher in human evolution. Richmond and collaborators examined anatomical evidence for a knuckle-walking ancestor, connecting comparative skeletal features with an explicitly testable hypothesis about human locomotor origins.[ref]
Evidence that humans evolved from a knuckle-walking ancestor by Brian G. Richmond and others. Author list and described study
Researcher in human evolution. White and collaborators investigated Ardipithecus ramidus, connecting fossil anatomy and environmental evidence with the interpretation of early hominin biology.[ref]
Ardipithecus ramidus and the paleobiology of early hominids by Tim D. White and others. Author list and described study
Researcher in primate evolution. Langergraber and collaborators measured generation times in wild chimpanzees and Gorillas, connecting life-history observations with estimates of when great-ape lineages diverged.[ref]
Marco Y. Hein investigated the human protein interaction network using quantitative measurements of interaction specificity, stoichiometry, and cellular abundance. These dimensions distinguish evidence that two proteins associate from the questions of how much complex is formed and how abundant its components are.[ref]
A human interactome in three quantitative dimensions organized by stoichiometries and abundances by Marco Y. Hein and others. 2015, abstract: quantitative specificity, stoichiometry and abundance dimensions
proximity labeling uses a localized reactive system to mark nearby molecules before extraction. The recovered label integrates access, distance, labeling rate and residence time; proximity alone does not demonstrate a direct protein-protein interaction.
dihydrofolate reductase catalyzes reduction of dihydrofolate to tetrahydrofolate using NADPH. Its catalytic cycle is a model for connecting protein dynamics, binding and release.
homeoviscous adaptation changes membrane composition in response to conditions such as growth temperature, helping preserve useful membrane dynamics. The original Escherichia coli study measured temperature-dependent fatty-acid changes and membrane-lipid viscosity by spin labeling.
Ken Matsuoka reconstituted COPII-coated vesicle formation with purified coat proteins and defined liposomes. Combining known components showed that membrane budding could be studied without the full complexity of an intact cell, while allowing the role of the lipid composition to be tested.[ref]
COPII-coated vesicle formation reconstituted with purified coat proteins and chemically defined liposomes by Ken Matsuoka and others. 1998, abstract and defined-liposome reconstitution with Sar1 and COPII subunits
Ornithine decarboxylase converts ornithine to putrescine with release of carbon dioxide, beginning a major route of polyamine biosynthesis. Its regulation includes binding to antizyme, which can inhibit activity and promote protein degradation. This gives a compact example of controlling a metabolic pathway by changing both catalytic availability and enzyme lifetime.
phosphatidylinositol is a glycerophospholipid with an inositol headgroup. phosphorylation of that headgroup produces distinct phosphoinositides.
Pinned article: Introduction to the OurBigBook Project
Welcome to the OurBigBook Project! Our goal is to create the perfect publishing platform for STEM subjects, and get university-level students to write the best free STEM tutorials ever.
Everyone is welcome to create an account and play with the site: ourbigbook.com/go/register. We belive that students themselves can write amazing tutorials, but teachers are welcome too. You can write about anything you want, it doesn't have to be STEM or even educational. Silly test content is very welcome and you won't be penalized in any way. Just keep it legal!
Intro to OurBigBook
. Source. We have two killer features:
- topics: topics group articles by different users with the same title, e.g. here is the topic for the "Fundamental Theorem of Calculus" ourbigbook.com/go/topic/fundamental-theorem-of-calculusArticles of different users are sorted by upvote within each article page. This feature is a bit like:
- a Wikipedia where each user can have their own version of each article
- a Q&A website like Stack Overflow, where multiple people can give their views on a given topic, and the best ones are sorted by upvote. Except you don't need to wait for someone to ask first, and any topic goes, no matter how narrow or broad
This feature makes it possible for readers to find better explanations of any topic created by other writers. And it allows writers to create an explanation in a place that readers might actually find it.
Figure 1. Screenshot of the "Derivative" topic page. View it live at: ourbigbook.com/go/topic/derivativeVideo 2. OurBigBook Web topics demo. Source. - local editing: you can store all your personal knowledge base content locally in a plaintext markup format that can be edited locally and published either:This way you can be sure that even if OurBigBook.com were to go down one day (which we have no plans to do as it is quite cheap to host!), your content will still be perfectly readable as a static site.
- to OurBigBook.com to get awesome multi-user features like topics and likes
- as HTML files to a static website, which you can host yourself for free on many external providers like GitHub Pages, and remain in full control
Figure 2. You can publish local OurBigBook lightweight markup files to either OurBigBook.com or as a static website.
Figure 3. Visual Studio Code extension installation.
Figure 5. . You can also edit articles on the Web editor without installing anything locally. Video 3. Edit locally and publish demo. Source. This shows editing OurBigBook Markup and publishing it using the Visual Studio Code extension. 
- Infinitely deep tables of contents:
All our software is open source and hosted at: github.com/ourbigbook/ourbigbook
Further documentation can be found at: docs.ourbigbook.com
Feel free to reach our to us for any help or suggestions: docs.ourbigbook.com/#contact