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Blood gas analysis characterizes a specified blood specimen using gas tensions and acid-base measurements. Core measured quantities include oxygen and carbon dioxide partial pressures and pH; instruments can also report derived quantities. Co-oximetry supplies related information about hemoglobin species by optical measurement rather than inferring all of them from gas tensions.[ref]
AARC Clinical Practice Guideline: Blood Gas Analysis and Hemoximetry: 2013 by Michael D. Davis and others. Section 1.0, Description, measured and derived variables
The specimen's source is part of the result. An arterial sample addresses a different compartment from a peripheral venous sample, where tissues have already exchanged gases with the blood. The sample is analyzed outside the circulation, so collection time, inspired gas, temperature convention and sample handling affect interpretation. The guideline identifies contamination, delay and temperature conventions as distinct limitations.[ref]
A calculation can look like an additional measurement. For an illustrative bicarbonate equilibrium approximation at a stated temperature, the Henderson-Hasselbalch equation can be writtenwith bicarbonate concentration in mmol/L and carbon-dioxide partial pressure in mmHg. The numerical constants specify this approximation; they are not universal across all temperatures and media. Rearranging givesFor stipulated pH 7.40 and mmHg, the calculated value is about 23.94 mmol/L. Holding pH fixed and changing that partial pressure to 60 mmHg raises the calculation to about 35.91 mmol/L. Those derived concentrations do not constitute a third independent observation validating the two inputs.
A sample-specific gas partial pressure also differs from total gas content. Much of transported oxygen is bound to hemoglobin, while measured oxygen tension concerns dissolved oxygen. A panel should therefore identify which values were directly measured, which were computed and which specimen supplied them. Agreement among quantities calculated from one another is internal arithmetic consistency, not independent physiological confirmation.
The Paschen law models gas-breakdown electric potential difference as a function of pressure times electrode spacing. For a uniform gap , fixed gas conditions and effective secondary-emission coefficient , an empirical ionization law together with givesHere , has units inverse to pressure times length, and has units of potential. The denominator must be positive. These constants and the fitted range are part of the model.[ref]
A Generalized Townsend's Theory for Paschen Curves in Planar, Cylindrical, and Spherical Geometries in Planetary Atmospheres by Jeremy A. Riousset and others. Equation (6), empirical Townsend coefficient; planar self-sustaining criterion
Writing and gives . Differentiation places its minimum at , with . A pressure sweep at fixed gap can therefore first lower and then raise the threshold. Nonuniform fields, changing cathode surfaces, temperature changes or microscopic gaps can break this scaling; it is not a universal law for every electrical spark.
The stance phase of a robot leg is the portion of a gait during which its foot is in the intended ground contact. It permits force transfer between the robot and its surroundings. Contact can occur with little load, and contact alone does not imply that the foot remains fixed without slipping. The swing phase instead transfers the foot toward another contact.
In an ideal rigid, nonadhesive contact model, let be the foot's normal gap above the ground and its normal contact force. The conditionsexclude penetration and tensile ground reaction. An open gap requires zero normal reaction; a zero gap permits a compressive reaction but does not require it to be strictly positive. The primary contact model distinguishes these unilateral constraints from the force/torque equations for equilibrium.[ref]
Robotic Systems by Kris Hauser. Chapter 12, Contact modeling and Equilibrium conditions
For an original level-ground example, take a robot supported by two stance feet, neglecting other external vertical forces. Newton's second law giveswhere is gravitational acceleration and is upward center of mass acceleration. With equal sharing and , each foot carries . With , each carries . Equal sharing is an additional symmetry assumption, not a consequence of knowing there are two contacts.
A simple Coulomb friction model constrains tangential force by . At zero vertical acceleration and , the two feet's combined horizontal-force capacity is at most in this planar model. Accelerating the body horizontally at would require and violate that bound. A stance-time schedule alone cannot remove this force limit. Individual contact geometry and torque balance can impose further constraints even when the combined bound passes.
For a periodic cycle, contact duration gives duty cycle . A proposed test records stance timing and forces separately, using calibrated sensors under the contacts together with body-motion measurements. It checks load transfer and slipping as well as touch timing. A support polygon is useful in an explicitly static planar model; dynamic stance additionally requires the changing force and momentum balance.
The swing phase of a robot leg is the interval in which its foot moves between ground contacts without providing the intended ground support. It complements the stance phase. In a periodic gait with period and contact duty cycle , its duration is . The leg can still require substantial actuator effort: moving its own mass and controlling its trajectory are different from supporting the robot through ground contact.
An original planar foot path gives an explicit design example. Let parameterize a swing of duration , horizontal travel and desired swing-foot clearance over a flat reference plane. ChooseBoth components have zero endpoint velocity. At mid-swing the foot has moved halfway horizontally and reaches height . The maximum horizontal and vertical speed magnitudes areFor , and , these are and about . Halving the available swing time doubles the path's speed requirements and quadruples its acceleration requirements. A contact schedule can therefore be feasible in timing arithmetic but too demanding for the actual leg.
The path is only a foot-level specification. Inverse kinematics must find joint configurations that realize it, and joint motion, collision and actuator constraints must also hold. Zero endpoint velocity does not guarantee continuous acceleration when this segment is joined to another trajectory. An uncertain or uneven ground height changes the actual clearance and contact time.
The primary contact-planning treatment distinguishes choosing contacts from moving through configuration space between them.[ref]
Robotic Systems by Kris Hauser. Chapter 12, Manipulation planning and locomotion planning and Multi-modal motion planning
A proposed robot test measures the foot path, the contact transition and joint response while changing swing duration or clearance. Calibrated sensors can distinguish premature ground contact from a trajectory-tracking error. The example above is an original motion prescription; it is not a measured gait or a complete stability controller.A trot in a quadrupedal robot coordinates diagonal leg pairs: front-left with hind-right, and front-right with hind-left. The two pairs alternate their stance phases and swing phases. The pairing and relative timing define the pattern; the fraction of each cycle spent in contact can vary.
For an original periodic model, take cycle period and normalized cycle phase . Let the front-left/hind-right pair have phase zero and the other pair have phase . Each foot remains in stance phase for fraction of the cycle. At , one diagonal pair contacts while the other swings, apart from the idealized transition instants.
The contact-time consequences follow directly. For , the diagonal-pair contacts do not overlap, and the fraction of the cycle with no foot contact isFor , the intervals overlap, and the fraction with all four feet in contact is . Thus gives 20% no-contact time, while gives 20% four-foot overlap. The average number of contacting feet is in either case, but an average does not describe the instantaneous support.
For stipulated and , each foot's stance lasts and swing lasts . Each pair overlaps the other for at each exchange, totaling per cycle. These are constructed timings, not measurements of a particular machine.
Two ideal diagonal point contacts have a support polygon reduced to a line segment. Static balance would require the projected center of mass to lie on that segment under the usual horizontal-plane assumptions, leaving no area margin to lateral disturbance. Dynamic motion additionally involves contact forces, angular momentum, friction and actuator limits. The contact and equilibrium models in the primary robotics text explain why a geometric schedule alone is insufficient.[ref]
Robotic Systems by Kris Hauser. Chapter 12, Contact modeling and Equilibrium conditions
A proposed robot trial records all foot-contact events, body motion and ground contact forces while commanding the diagonal pattern. It checks whether the planned duty fraction and phase offsets are realized and whether motion remains feasible. Contact timing identifies the gait; the force and motion records test its execution.
A gigahertz is hertz, or cycles per second. The prefix giga supplies the exact factor . A periodic signal at has period .[ref]
The International System of Units (SI), ninth edition, SI Brochure. Sections 2.3.4 and 3, hertz and SI prefixes
The corresponding angular frequency is , so means . Keeping this distinction explicit prevents a factor of error in wave and oscillator equations.
Primary drying is the freeze-drying stage in which ice is removed mainly by sublimation. Frozen water becomes water vapor without first becoming bulk liquid water. This distinguishes it from secondary drying, which addresses residual sorbed water after the main ice-removal stage.[ref]
Lyophilization of Parenteral (7/93) by the Food and Drug Administration. Introduction: freezing, primary drying/sublimation and secondary drying/desorption.
A simple physical balance explains why removing frozen water still requires energy. If a mass of ice sublimes and the relevant specific latent heat is , the idealized energy requirement isFor an illustrative and assumed , this gives . The example neglects heating of the remaining material and heat losses; it is an energy inventory rather than a drying schedule.
Thus reducing pressure does not remove the need for heat transfer. The phase change consumes energy while vapor must leave the material. A decrease in sample mass can establish removal of matter under appropriate assumptions, but identifying primary drying also requires evidence that the removed water was initially ice and followed the sublimation route.
Secondary drying is the freeze-drying stage concerned with removing residual sorbed water after the main ice-removal step. Its central description is desorption, whereas primary drying is described chiefly by sublimation. A sample can therefore have no remaining bulk ice yet still contain water associated with its solid material.[ref]
Lyophilization of Parenteral (7/93) by the Food and Drug Administration. Introduction: primary drying by sublimation and secondary drying by desorption.
An original mass example shows why this distinction matters quantitatively. Suppose the dry solid contributes and a partly dried specimen weighs . It initially retains of water under these assumptions. A later mass of would leave of water. The removed is 70% of the initially residual water, while it is only about 2.69% of the earlier total specimen mass.
A large relative change in residual moisture can therefore accompany a small change in overall mass. That calculation is conditional on unchanged dry-solid mass and no chemical reaction; the mass data alone do not distinguish desorption from every other possible cause of mass loss. The physical interpretation and the choice of denominator must accompany the reported moisture result.
A framebuffer stride is the memory address increment between the starts of consecutive image rows in a specified framebuffer layout. For a row-based packed pixel format, it is commonly measured in bytes. It includes any padding between rows, so the image width and pixel format alone do not determine it. The Linux frame-buffer interface reports this byte count as
fb_fix_screeninfo.line_length.[ref]The Frame Buffer Device API in the Linux Kernel documentation. Section2, FB_TYPE_PACKED_PIXELS and end-of-line padding; section3, line_length
Assume each pixel occupies complete bytes, rows advance by a positive stride , and coordinates are zero-based. With base address ,This formula describes the stated packed-row layout. Formats with a different organization need their own addressing rule.
For an original example, choose an image width , height and per pixel. The pixel data in each row occupies 15 bytes. If the chosen allocator aligns each row to a multiple of eight bytes, it usesThere is one padding byte per row slot. The last pixel, at , starts at and occupies offsets 44, 45 and 46. Three complete row slots occupy 48 bytes, whereas the span through the last pixel ends at exclusive offset47:The allocation rule and the bytes actually containing pixels are distinct parts of the layout.
A cropped view need not become tightly packed. Starting a three-pixel-wide crop at original coordinate gives new base . Its next row still begins at , although each cropped row contains only nine pixel bytes. Substituting nine for the stride would instead start that row at .
Query the actual layout supplied by the interface before traversing memory. In the documented Linux interface, a successful format change can also update
line_length, so the stride belongs to the selected layout rather than being an immutable consequence of visible width.[ref]The Frame Buffer Device API in the Linux Kernel documentation. Section4, format configuration and updated type, visual and line_length fields
Linear elastic fracture mechanics predicts the loading of a crack using linear elasticity outside a small region near its tip. The near-tip stress field has a characteristic dependence; its amplitude is the stress intensity factor. For an opening crack under nominal tensile stress ,where is a specified crack-length parameter and a dimensionless geometry factor. A central crack in an effectively infinite plate has total length and . Crack advance is assessed by comparing with the appropriate measured fracture toughness.[ref]
For and in that ideal geometry, . Increasing the crack's half-length fourfold doubles without changing the applied stress. This explains why a structure can fail at a stress below the strength of an uncracked specimen.
A toughness measurement loads a precracked specimen of known geometry and records the force associated with crack extension. Thickness, remaining ligament and crack length must be large relative to the crack-tip plastic region before the plane-strain value is transferable in this model. Large-scale plastic deformation requires a different description; the elastic singularity is a useful outer approximation, not an assertion of physically infinite stress inside the material.[ref]
Introduction to Fracture Mechanics by David Roylance. printed pp.9–11, specimen geometry, plastic zone and plane strain
A body fossil preserves evidence of an organism's body or a part of it, such as a tooth, bone, shell or leaf. Preservation can retain original material, a mineralized structure, an impression or a cast. A body fossil therefore need not be an intact body or contain the original organic substances.
A trace fossil, such as a footprint or burrow, records activity rather than the body itself. Both are biological evidence, but they answer different questions: a tooth can constrain anatomy, whereas a trackway can constrain movement. Decay experiments show why preserved anatomy requires care: some characters disappear before others, biasing the apparent similarities used in phylogenetics.[ref]
Non-random decay of chordate characters causes bias in fossil interpretation by Robert S. Sansom and others. Experimental character-loss sequences and their consequences for fossil reconstruction
A formazan optical response is an observed optical signal associated with a specified formazan derivative and its physical/chemical state. It can depend on dissolved product concentration, wavelength, solvent, optical geometry and suspended material. The family name alone does not supply one universal molar absorption coefficient.
For a suitable dissolved-product measurement, the Beer-Lambert law givesHere is absorbance, the relevant background, the geometric light path, dissolved amount and solution volume, with compatible units. In a fixed-path cuvette, doubling volume at fixed amount halves the ideal product absorbance.
A vertical measurement through an ideal parallel-sided well behaves differently. If well area is , fill height is , soThis microplate fill-height optical cancellation assumes the same represented area and optical geometry. Dilution lowers concentration while increasing path length, so the volume factors cancel. A real well's meniscus, beam geometry and instrument processing can require a more detailed model; this is not a universal correction for every plate reader.
A controlled dilution check should therefore specify whether path length is fixed or changes with fill height. In an original fixed-path example, product contribution plus a constant optical background gives raw absorbance . Halving product concentration with that same background gives , not half the initial raw value. Subtracting the correct background recovers product contributions and .
The manufacturer's MTT principle separates formation of formazan crystals from their later dissolution and multiwell measurement.[ref] Visible particles can introduce light scattering, which is not automatically described by a dissolved-dye absorption law. An MTT formazan solubilization check addresses this physical stage.
A spectrum or a single absorbance value is an optical observation. Inferring cell viability additionally requires a validated biochemical response model, because tetrazolium-reduction interference can produce the same colored material without the intended cellular mechanism.
The tangent stiffness at a point on a differentiable force-displacement curve is its local slope,It governs the first-order response to a small displacement change:The graphical interpretation is the slope of the tangent line. Structural stiffness measured from force-deflection behaviour includes geometry as well as material response.[ref]
Structural Stiffness Concept by TU Delft OpenCourseWare. Discussion following the axial force-displacement relation
For the illustrative model , choose and . At , the tangent stiffness is . An additional therefore predicts a force increase of to first order. Direct substitution gives ; the difference is the higher-order contribution omitted by the tangent approximation. The secant stiffness from the origin is only at this point.
In a displacement-controlled experiment, one can estimate the local slope with a central finite difference,Making smaller reduces the approximation error for a smooth exact curve, but measured differences can become dominated by measurement uncertainty. The force channel, displacement channel and loading branch must therefore be specified. Crosshead movement can include machine mechanical compliance, while an extensometer records a selected specimen extension.[ref]
Extensometers in the Instron documentation. When to use an extensometer: machine compliance, grip seating and load-train deflection
For a curve with hysteresis, loading and unloading can have different local slopes at the same displacement. At a sharp corner a unique derivative may not exist, and a finite-interval slope should be reported as such.
Pinned article: Introduction to the OurBigBook Project
Welcome to the OurBigBook Project! Our goal is to create the perfect publishing platform for STEM subjects, and get university-level students to write the best free STEM tutorials ever.
Everyone is welcome to create an account and play with the site: ourbigbook.com/go/register. We belive that students themselves can write amazing tutorials, but teachers are welcome too. You can write about anything you want, it doesn't have to be STEM or even educational. Silly test content is very welcome and you won't be penalized in any way. Just keep it legal!
Intro to OurBigBook
. Source. We have two killer features:
- topics: topics group articles by different users with the same title, e.g. here is the topic for the "Fundamental Theorem of Calculus" ourbigbook.com/go/topic/fundamental-theorem-of-calculusArticles of different users are sorted by upvote within each article page. This feature is a bit like:
- a Wikipedia where each user can have their own version of each article
- a Q&A website like Stack Overflow, where multiple people can give their views on a given topic, and the best ones are sorted by upvote. Except you don't need to wait for someone to ask first, and any topic goes, no matter how narrow or broad
This feature makes it possible for readers to find better explanations of any topic created by other writers. And it allows writers to create an explanation in a place that readers might actually find it.Figure 1. Screenshot of the "Derivative" topic page. View it live at: ourbigbook.com/go/topic/derivativeVideo 2. OurBigBook Web topics demo. Source. - local editing: you can store all your personal knowledge base content locally in a plaintext markup format that can be edited locally and published either:This way you can be sure that even if OurBigBook.com were to go down one day (which we have no plans to do as it is quite cheap to host!), your content will still be perfectly readable as a static site.
- to OurBigBook.com to get awesome multi-user features like topics and likes
- as HTML files to a static website, which you can host yourself for free on many external providers like GitHub Pages, and remain in full control
Figure 2. You can publish local OurBigBook lightweight markup files to either OurBigBook.com or as a static website.Figure 3. Visual Studio Code extension installation.Figure 5. . You can also edit articles on the Web editor without installing anything locally. Video 3. Edit locally and publish demo. Source. This shows editing OurBigBook Markup and publishing it using the Visual Studio Code extension. - Infinitely deep tables of contents:
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