Topics (384k) Articles (398k) Users (410) Discussions (242) Comments (383) Files (13k) New article
Researcher in RNA structure and regulation. Liu and collaborators investigated modification-dependent RNA structural switches, connecting N6-methyladenosine with changes in accessibility to RNA-binding proteins.[ref]
Researcher in RNA measurement. Herzog and collaborators developed thiol-linked alkylation for following RNA-expression dynamics, connecting a chemical labeling strategy with estimates of transcript production and persistence.[ref]
Thiol-linked alkylation of RNA to assess expression dynamics by Veronika A. Herzog and others. Title, author list and reported study
Researcher in RNA regulation. Huang and collaborators investigated recognition of N6-methyladenosine by IGF2BP protein proteins, connecting an RNA modification with transcript stability and translation.[ref]
Researcher in transcription. Core and collaborators measured nascent RNA to compare initiation regions at promoters and enhancers, connecting the earliest transcription products with the organization of regulatory DNA.[ref]
Researcher in transcriptional regulation. Vo ngoc and collaborators investigated the position and prevalence of the human initiator element, connecting a short core-promoter sequence with focused transcription initiation.[ref]
Researcher in chemical biology. Titov and collaborators identified XPB as a target of triptolide, connecting a small molecule’s activity with a component of the TFIIH machinery.[ref]
XPB, a subunit of TFIIH, is a target of the natural product triptolide by Denis V. Titov and others. Title, author list and reported study
Researcher in epigenetics. Hathaway and collaborators investigated the dynamics and memory of heterochromatin in living cells, connecting controlled recruitment of regulators with persistence of a cellular state.[ref]
Dynamics and Memory of Heterochromatin in Living Cells by Nathaniel A. Hathaway and others. Title, author list and reported study
Researcher in heterochromatin. Verdel and collaborators investigated targeting by the RITS complex, connecting small-RNA-guided recognition with recruitment of chromatin-silencing machinery.[ref]
RNAi-mediated targeting of heterochromatin by the RITS complex by André Verdel and others. Title, author list and reported study
Researcher in heterochromatin. Volpe and collaborators investigated RNA interference in gene silencing and histone-H3 lysine-9 methylation, connecting small-RNA pathways with formation of a repressive chromatin state.[ref]
Researcher in genome regulation. Rowe and collaborators investigated KAP1 control of endogenous retroviruses in embryonic stem cells, connecting a chromatin regulator with repression of integrated viral sequences.[ref]
KAP1 controls endogenous retroviruses in embryonic stem cells by Helen M. Rowe and others. Title, author list and reported study
Researcher in developmental RNA localization. With Elizabeth R. Gavis, Forrest used live imaging to investigate diffusion and entrapment of nanos messenger RNA, connecting observed RNA motion with a mechanism of selective retention.[ref]
Researcher in localized translation. Hüttelmaier and collaborators investigated Src-dependent phosphorylation of ZBP1 in control of beta-actin translation, connecting a signaling event with where a protein is synthesized.[ref]
Researcher in translational control. Darnell and collaborators studied differential ribosome pausing during amino acid limitation, connecting nutrient availability with selective changes in protein production.[ref]
Researcher in cellular stress responses. Harding and collaborators investigated how regulation of translation initiation controls stress-induced gene expression, connecting reduced general protein synthesis with selective production of response proteins.[ref]
Researcher in translational control. With Ronald C. Wek, Vattem investigated ATF4 regulation by upstream reading frames, connecting reinitiation of translation with selective expression during cellular stress.[ref]
Researcher in nutrient sensing. Wolfson and collaborators investigated Sestrin2 as a leucine sensor for the mTORC1 pathway, connecting availability of a particular amino acid with growth-regulating signaling.[ref]
Sestrin2 is a leucine sensor for the mTORC1 pathway by Rachel L. Wolfson and others. Title, author list and reported study
Researcher in structural biology. Brown and collaborators investigated ribosome-dependent activation of stringent control, connecting the structural state of the translation machinery with bacterial responses to nutrient limitation.[ref]
Ribosome-dependent activation of stringent control by Alan Brown and others. Title, author list and reported study
Researcher in plastid gene regulation. Hajdukiewicz and collaborators investigated how nuclear-encoded and plastid-encoded RNA polymerases transcribe distinct gene groups, connecting two transcription systems with division of labor in an organelle.[ref]
Researcher in plant gene regulation. Nagashima and collaborators studied activation of a light-responsive chloroplast promoter by SIG5, connecting environmental responses with specialized transcription machinery.[ref]
Pinned article: Introduction to the OurBigBook Project
Welcome to the OurBigBook Project! Our goal is to create the perfect publishing platform for STEM subjects, and get university-level students to write the best free STEM tutorials ever.
Everyone is welcome to create an account and play with the site: ourbigbook.com/go/register. We belive that students themselves can write amazing tutorials, but teachers are welcome too. You can write about anything you want, it doesn't have to be STEM or even educational. Silly test content is very welcome and you won't be penalized in any way. Just keep it legal!
Intro to OurBigBook
. Source. We have two killer features:
- topics: topics group articles by different users with the same title, e.g. here is the topic for the "Fundamental Theorem of Calculus" ourbigbook.com/go/topic/fundamental-theorem-of-calculusArticles of different users are sorted by upvote within each article page. This feature is a bit like:
- a Wikipedia where each user can have their own version of each article
- a Q&A website like Stack Overflow, where multiple people can give their views on a given topic, and the best ones are sorted by upvote. Except you don't need to wait for someone to ask first, and any topic goes, no matter how narrow or broad
This feature makes it possible for readers to find better explanations of any topic created by other writers. And it allows writers to create an explanation in a place that readers might actually find it.
Figure 1. Screenshot of the "Derivative" topic page. View it live at: ourbigbook.com/go/topic/derivativeVideo 2. OurBigBook Web topics demo. Source. - local editing: you can store all your personal knowledge base content locally in a plaintext markup format that can be edited locally and published either:This way you can be sure that even if OurBigBook.com were to go down one day (which we have no plans to do as it is quite cheap to host!), your content will still be perfectly readable as a static site.
- to OurBigBook.com to get awesome multi-user features like topics and likes
- as HTML files to a static website, which you can host yourself for free on many external providers like GitHub Pages, and remain in full control
Figure 2. You can publish local OurBigBook lightweight markup files to either OurBigBook.com or as a static website.
Figure 3. Visual Studio Code extension installation.
Figure 5. . You can also edit articles on the Web editor without installing anything locally. Video 3. Edit locally and publish demo. Source. This shows editing OurBigBook Markup and publishing it using the Visual Studio Code extension. 
- Infinitely deep tables of contents:
All our software is open source and hosted at: github.com/ourbigbook/ourbigbook
Further documentation can be found at: docs.ourbigbook.com
Feel free to reach our to us for any help or suggestions: docs.ourbigbook.com/#contact