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Researcher in yeast genetics and RNA polymerases. Thuriaux and collaborators identified RPA43 as encoding an essential subunit of RNA polymerase I; gene disruption and rescue experiments connected the subunit with ribosomal-RNA synthesis.[ref]
Researcher in centromere biology. Nergadze and collaborators studied the origin, inheritance and evolution of mammalian centromeres lacking the satellite repeats often associated with these chromosome regions.[ref]
Researcher in chromatin organization. Farr and collaborators investigated how nucleosome flexibility contributes to biomolecular phase separation and interactions between nucleosomes.[ref]
Researcher whose work investigated centromere formation and chromosome identity. Shang and collaborators studied how a functional centromere can be specified through cellular and chromatin context rather than inferred solely from a familiar repeated DNA sequence.[ref]
Writer on evolution whose Mutual Aid examined cooperation among animals. Kropotkin emphasized that relations among organisms include mutual support, placing cooperative behavior within the discussion of survival and evolutionary explanation.[ref]
Mutual Aid: A Factor of Evolution by Peter Kropotkin. Author list and described study
Portrait of Peter Kropotkin
. F. Nadar; source: NYPL. Public domain (author died 1910; published before 1931). Source usage terms, via Wikimedia Commons. Source.Researcher in cancer genomics whose experiments connected damage in micronuclei with chromothripsis. This links an abnormal cellular compartment with the concentrated rearrangement of a chromosome, helping explain how many genome changes can arise together.[ref]
Researcher in systems biology who coauthored a control-theoretic explanation of robust adaptation in chemotaxis. The study connected recovery of a signaling output after stimulation with integral feedback, showing how a biological circuit can implement a general control principle.[ref]
Researcher in bioinformatics who coauthored a study of gene names corrupted in scientific spreadsheets. Automatic conversion of gene symbols into dates or other formats can alter identifiers without an obvious warning, making data handling part of scientific reproducibility.[ref]
Researcher in neuroimaging and coauthor of work examining false positives in clustered functional magnetic resonance imaging results. The study revisited assumptions used to assign significance to spatial patterns, illustrating why analysis software and its statistical model must be evaluated together.[ref]
Researcher in whole-cell modeling. Karr and collaborators integrated models of cellular processes in Mycoplasma genitalium, using experimental measurements to test predicted behavior. The 2012 model illustrates how combining processes can reveal consequences that are difficult to infer from each process in isolation.[ref]
Researcher in developmental biology. Sulston and collaborators reconstructed the embryonic cell lineage of Caenorhabditis elegans, connecting divisions of individual cells with the reproducible organization of a developing animal.[ref]
The embryonic cell lineage of the nematode Caenorhabditis elegans by John Sulston and others. Author list and described study
Portrait of John Sulston
. PLoS. CC BY 2.5, via Wikimedia Commons. Source.Researcher in single-cell biology whose work connected molecular measurements with the embryonic cell lineage of Caenorhabditis elegans. Packer and collaborators assembled an atlas that associates developing cells with their expression states and developmental histories, making a molecular description comparable with a lineage map.[ref]
Researcher in computational biology and coauthor of the OpenWorm overview. This project uses Caenorhabditis elegans to connect models of interacting biological processes into whole-organism modeling; integration makes the assumptions and interfaces between models central scientific questions.[ref]
Researcher in computational biology and author of scGen, a method for predicting responses to perturbation from single-cell measurements. The work uses machine learning to connect a cell’s observed state with an estimated response to a changed condition.[ref]
Evolutionary biologist who, with Peter R. Grant, studied Darwin's finches over decades. Repeated field measurements connected selection and hybridization with changing beak and body traits, revealing events that a short observation period could miss.[ref]
Unpredictable evolution in a 30-year study of Darwin's finches by Peter R. Grant and B. Rosemary Grant. Author list and described study
Portrait of B. Rosemary Grant
. David Craig. CC BY-SA 2.0, via Wikimedia Commons. Source.Researcher in gene regulation and evolutionary developmental biology. Kvon and collaborators tested snake versions of the ZRS enhancer in mice: replacing the mouse regulatory sequence with snake sequences reduced limb development, while restoring a lost binding site could restore enhancer function. The experiment connects changes in a regulatory DNA sequence with an evolutionary change in body form.[ref]
Researcher studying the relationship between gene regulation, environment and visible traits. Gibert and collaborators investigated temperature-dependent pigmentation in Drosophila, linking phenotypic plasticity to a network of chromatin regulators.[ref]
Researcher in RNA biology and coauthor of experiments showing that excised linear introns can regulate growth in yeast. The work challenges the assumption that an intron necessarily becomes functionless waste immediately after RNA splicing.[ref]
Evolutionary biologist who, with Martin Kreitman, compared synonymous and amino acid-changing differences within and between Drosophila species. Their 1991 analysis supplied a statistical test of neutral evolution: under the proposed neutral baseline, the two kinds of difference should occur in the same ratio within and between species.[ref]
Pinned article: Introduction to the OurBigBook Project
Welcome to the OurBigBook Project! Our goal is to create the perfect publishing platform for STEM subjects, and get university-level students to write the best free STEM tutorials ever.
Everyone is welcome to create an account and play with the site: ourbigbook.com/go/register. We belive that students themselves can write amazing tutorials, but teachers are welcome too. You can write about anything you want, it doesn't have to be STEM or even educational. Silly test content is very welcome and you won't be penalized in any way. Just keep it legal!
Intro to OurBigBook
. Source. We have two killer features:
- topics: topics group articles by different users with the same title, e.g. here is the topic for the "Fundamental Theorem of Calculus" ourbigbook.com/go/topic/fundamental-theorem-of-calculusArticles of different users are sorted by upvote within each article page. This feature is a bit like:
- a Wikipedia where each user can have their own version of each article
- a Q&A website like Stack Overflow, where multiple people can give their views on a given topic, and the best ones are sorted by upvote. Except you don't need to wait for someone to ask first, and any topic goes, no matter how narrow or broad
This feature makes it possible for readers to find better explanations of any topic created by other writers. And it allows writers to create an explanation in a place that readers might actually find it.
Figure 1. Screenshot of the "Derivative" topic page. View it live at: ourbigbook.com/go/topic/derivativeVideo 2. OurBigBook Web topics demo. Source. - local editing: you can store all your personal knowledge base content locally in a plaintext markup format that can be edited locally and published either:This way you can be sure that even if OurBigBook.com were to go down one day (which we have no plans to do as it is quite cheap to host!), your content will still be perfectly readable as a static site.
- to OurBigBook.com to get awesome multi-user features like topics and likes
- as HTML files to a static website, which you can host yourself for free on many external providers like GitHub Pages, and remain in full control
Figure 2. You can publish local OurBigBook lightweight markup files to either OurBigBook.com or as a static website.
Figure 3. Visual Studio Code extension installation.
Figure 5. . You can also edit articles on the Web editor without installing anything locally. Video 3. Edit locally and publish demo. Source. This shows editing OurBigBook Markup and publishing it using the Visual Studio Code extension. 
- Infinitely deep tables of contents:
All our software is open source and hosted at: github.com/ourbigbook/ourbigbook
Further documentation can be found at: docs.ourbigbook.com
Feel free to reach our to us for any help or suggestions: docs.ourbigbook.com/#contact