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Immunologist whose experiments helped establish MHC restriction. Zinkernagel and collaborators tested T-cell-mediated killing in viral infection, showing that recognition depends on the target’s compatibility with the responding immune cells.[ref]
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Portrait of Rolf M. Zinkernagel
. Aasemsj; cropped by Wabbuh. CC BY-SA 3.0, via Wikimedia Commons. Source.Researcher in structural biology. Lee and collaborators investigated the torque-generating ring of the bacterial flagellar motor and its rotational switching, connecting molecular architecture with a change in the direction of motion.[ref]
Researcher in epigenetic inheritance. Singh and collaborators studied how small RNAs associated with genome defense were recruited for inheritance of mating type, an example of an existing molecular mechanism acquiring a new biological role.[ref]
Researcher in comparative physiology. Albert F. Bennett and collaborators investigated the relationship between endothermy and activity in vertebrates, connecting heat production with the physiological capacity to sustain behavior.[ref]
Endothermy and activity in vertebrates by Albert F. Bennett and others. Title, author list and reported study
Researcher in vertebrate physiology. Farmer proposed a connection between parental care and the evolution of endothermy, using reproductive investment to frame hypotheses about the convergent biology of birds and mammals.[ref]
Researcher in systems biology. With Uri Alon, Mangan analyzed the structure and function of the feed-forward loop, a recurring arrangement in which an upstream regulator acts on a target both directly and through another regulator.[ref]
Structure and function of the feed-forward loop network motif by Shmoolik Mangan and Uri Alon. Title, author list and reported study
Researcher in systems biology. With Shmoolik Mangan, Alon studied how the feed-forward loop links a small network’s pattern of connections with its dynamical function, connecting biological regulation with quantitative models.[ref]
Structure and function of the feed-forward loop network motif by Shmoolik Mangan and Uri Alon. Title, author list and reported study
Portrait of Uri Alon
. Weizmann Institute of Science; public-domain release confirmed through Wikimedia VRT. Public domain (copyright-holder release). Source and usage information on the linked Wikimedia file page. Source.Researcher in cell cycle control. Caydasi and collaborators studied activation of Kin4 by Elm1, helping explain the signaling mechanism of the spindle position checkpoint.[ref]
Elm1 kinase activates the spindle position checkpoint kinase Kin4 by Ayse Koca Caydasi and others. Title, author list and reported study
Researcher in live-cell genome imaging. Chen and collaborators adapted CRISPR-Cas9 targeting to visualize particular DNA loci in living human cells, connecting sequence recognition with observations of chromosome dynamics.[ref]
Researcher in chromatin organization. Gibson and collaborators investigated intrinsic and regulated phase separation of chromatin, testing how interactions among its components can generate collective organization.[ref]
Organization of Chromatin by Intrinsic and Regulated Phase Separation by Bryan A. Gibson and others. Title, author list and reported study
Researcher in live-cell chromatin imaging. Robinett and collaborators used recognition between the lac operator and repressor to mark DNA regions in living cells, making chromosome organization observable through a genetically specified tag.[ref]
Researcher in asymmetric cell division. Yuan and collaborators studied the dependence of the centrosome orientation checkpoint on cyclin A localization downstream of Par-1, linking cell polarity with the timing of division.[ref]
Researcher studying stem cells and aging. Cheng and collaborators linked centrosome misorientation with reduced stem-cell division, providing a cellular mechanism through which tissue maintenance can change with age.[ref]
Centrosome misorientation reduces stem cell division during aging by Jun Cheng and others. Title, author list and reported study
Researcher in cell cycle control. D’Aquino and collaborators studied how Kin4 inhibits exit from mitosis when the spindle apparatus is incorrectly positioned, connecting spatial organization with checkpoint control.[ref]
Researcher in chromosome segregation and chromatin organization. Nasmyth’s laboratory investigated how cohesin holds sister DNA molecules together and how related molecular complexes organize loops, connecting molecular topology with accurate cell division.[ref]
https://www.bioch.ox.ac.uk/research/nasmyth. Research description, cohesin-mediated entrapment and loop extrusion
Portrait of Kim Nasmyth
. Jimcricket90. CC BY-SA 4.0, via Wikimedia Commons. Source.Geneticist whose experiments used yeast mutants to identify genes controlling the cell cycle. Isolating mutants that fail at particular stages makes the order and genetic requirements of cellular events experimentally accessible.[ref]
Researcher studying asymmetric cell division. Inaba and collaborators investigated how the polarity protein Baz positions the centrosome in the male Drosophila germline, connecting intracellular organization with the orientation of a stem-cell division.[ref]
Researcher studying bacterial persistence. Balaban and collaborators followed individual biological cells to distinguish transient survival during antibiotic exposure from inherited antibiotic resistance. This makes a cell’s physiological state and history relevant to the interpretation of population survival.[ref]
Pinned article: Introduction to the OurBigBook Project
Welcome to the OurBigBook Project! Our goal is to create the perfect publishing platform for STEM subjects, and get university-level students to write the best free STEM tutorials ever.
Everyone is welcome to create an account and play with the site: ourbigbook.com/go/register. We belive that students themselves can write amazing tutorials, but teachers are welcome too. You can write about anything you want, it doesn't have to be STEM or even educational. Silly test content is very welcome and you won't be penalized in any way. Just keep it legal!
Intro to OurBigBook
. Source. We have two killer features:
- topics: topics group articles by different users with the same title, e.g. here is the topic for the "Fundamental Theorem of Calculus" ourbigbook.com/go/topic/fundamental-theorem-of-calculusArticles of different users are sorted by upvote within each article page. This feature is a bit like:
- a Wikipedia where each user can have their own version of each article
- a Q&A website like Stack Overflow, where multiple people can give their views on a given topic, and the best ones are sorted by upvote. Except you don't need to wait for someone to ask first, and any topic goes, no matter how narrow or broad
This feature makes it possible for readers to find better explanations of any topic created by other writers. And it allows writers to create an explanation in a place that readers might actually find it.
Figure 1. Screenshot of the "Derivative" topic page. View it live at: ourbigbook.com/go/topic/derivativeVideo 2. OurBigBook Web topics demo. Source. - local editing: you can store all your personal knowledge base content locally in a plaintext markup format that can be edited locally and published either:This way you can be sure that even if OurBigBook.com were to go down one day (which we have no plans to do as it is quite cheap to host!), your content will still be perfectly readable as a static site.
- to OurBigBook.com to get awesome multi-user features like topics and likes
- as HTML files to a static website, which you can host yourself for free on many external providers like GitHub Pages, and remain in full control
Figure 2. You can publish local OurBigBook lightweight markup files to either OurBigBook.com or as a static website.
Figure 3. Visual Studio Code extension installation.
Figure 5. . You can also edit articles on the Web editor without installing anything locally. Video 3. Edit locally and publish demo. Source. This shows editing OurBigBook Markup and publishing it using the Visual Studio Code extension. 
- Infinitely deep tables of contents:
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All our software is open source and hosted at: github.com/ourbigbook/ourbigbook
Further documentation can be found at: docs.ourbigbook.com
Feel free to reach our to us for any help or suggestions: docs.ourbigbook.com/#contact