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A diagnostic example is technetium-99m methylene diphosphonate, which accumulates at sites of bone turnover for bone scintigraphy. A therapeutic example is sodium iodide iodine-131, taken up by thyroid tissue and used for selected thyroid disease including differentiated thyroid cancer.

For diagnosis, an escaping gamma ray or a Positron followed by annihilation photons allows external detection, with an appropriate short half-life and limited deposited energy. For molecular radiotherapy, short-range charged emissions such as beta particles, alpha particles or Auger electrons deposit substantial local energy in the targeted tissue. Iodine-131 emits therapeutic beta particles as well as imageable gamma rays, so these categories are functional rather than mutually exclusive isotope classes.

After thermalization, approximate the electron and Positron as initially at rest in their centre-of-momentum frame. Their total energy is $2m_e{c}^2$ and total momentum is zero. Two photons must therefore have equal energies and opposite momenta, since $|{\mathbf{p}}_{\gamma }|=E_{\gamma }/c$. Conservation of energy givesResidual pair momentum and electron binding cause small departures from exact collinearity and exact photon energy; the standard PET calculation neglects them.

Define the positive mass collision stopping power as $S_{\mathrm{col}}/\rho =-(1/\rho )dT/dx$. For a projectile of charge $ze$, mass $M\gg m_e$, speed $v=\beta c$ and Lorentz factor $\Gamma =(1-{\beta }^2{)}^{-1/2}$, the Bethe stopping formula can be writtenHere $Z$ is the absorber atomic number, $A$ its molar mass, $I$ its mean excitation energy, $r_e=e^2/(4\pi {ϵ}_0{m}_e{c}^2)$, and $N_A$ the Avogadro constant. AlsoThe optional $\delta$ and $C/Z$ represent density and shell corrections. For a very heavy projectile $T_{\max }\simeq 2m_e{c}^2{\beta }^2{\Gamma }^2$, and the bracket reduces to $\ln (2m_e{c}^2{\beta }^2{\Gamma }^2/I)-{\beta }^2$ when those corrections are neglected. If $T$ denotes remaining projectile kinetic energy, the printed $dT/(\rho dx)$ is negative; the conventional positive stopping power has the minus sign above.^[ref]

Start with a fast massive projectile following an approximately straight path. Its time-dependent electric field perturbs bound absorber electrons. At large impact parameter, treating the perturbation to first order and summing excitation and ionization transition probabilities gives an energy transfer weighted by the absorber's oscillator strengths. The oscillator-strength sum rule reduces the leading coefficient to the number of target electrons, while their logarithmically weighted excitation energies define $I$.

The classical impulse picture explains the logarithm: a transverse impulse scales as $1/(bv)$, so transferred energy scales as $1/(b^2{v}^2)$; multiplying by the number of encountered electrons in $2\pi bdbdx$ gives $db/b$. Quantum scattering replaces ad hoc short- and long-distance cutoffs by recoil kinematics and bound-state excitation. Relativistic projectile kinematics supplies $T_{\max }$ and the $-{\beta }^2$ term. Summation over many independent encounters gives the mean stopping power, rather than the energy-loss straggling of individual tracks.

The leading approximation assumes $M\gg m_e$, a sufficiently fast projectile for perturbation theory, a largely fixed projectile charge, and weak correlations between collisions. At low velocity, electron binding, charge exchange and nuclear stopping become important; at high velocity, polarization screens distant interactions and gives the density correction. The projectile's bremsstrahlung is suppressed by its large mass and is excluded from the collision stopping power.

The dominant $z^2/{\beta }^2$ factor raises the energy loss as a charged projectile slows, while the logarithm moderates that rise. This produces a Bragg peak close to the end of its particle range. At still lower velocity, changing effective charge, shell effects and nuclear stopping invalidate extrapolation of the elementary Bethe stopping formula to zero energy. A finite initial energy gives a finite continuous-slowing-down range,A higher initial energy increases the particle range; greater electron density increases stopping power per unit length. Absorber $Z/A$ and $I$ also affect the depth. Multiple Coulomb scattering, energy-loss straggling, nuclear reactions and the incident energy spread broaden the measured peak and distal fall-off; nuclear secondaries can produce a small tail. Superposing many incident energies makes a spread-out Bragg peak for an extended target. The schematic curve below illustrates shapes only and is not patient radiation dosimetry.

Photon radiotherapy uses indirectly ionizing photons. Their Compton scattering, photoelectric effect and, at higher energy, pair production create charged particles that deposit energy. A megavoltage beam has a dose-build-up region followed by a gradual decline and substantial exit dose. Multiple shaped beams or intensity-modulated radiotherapy distribute this dose around a target.

Proton therapy uses directly ionizing charged particles with a finite particle range and a Bragg peak. Tuning beam energy controls depth and scanning controls lateral delivery; multiple energies cover a finite target thickness. Reduced distal and integral normal-tissue dose is a potential advantage. Limitations include range uncertainty, Multiple Coulomb scattering, nuclear secondary production, motion-dependent delivery, and a variable relative biological effectiveness, particularly near the distal edge. A physical dose advantage must be assessed against target coverage and clinically relevant toxicity; it does not by itself establish superior tumour control.

The left panel below shows paddles in a bath connected by an axle to an asymmetric toothed wheel, a spring-loaded pawl and a load. A naive argument lets random paddle kicks turn the wheel in one direction while the pawl blocks reverse motion, apparently extracting work from a single bath. The missing ingredient is the pawl's own thermal fluctuations. At the same temperature, it sometimes lifts and allows reverse slips. Correct forward and reverse transition rates obey detailed balance, so no sustained directed rotation can do work at single-bath thermal equilibrium. The device illustrates, rather than disproves, the Second law of thermodynamics.

A macroscopic shaken ratchet is driven far from thermal equilibrium: imposed shaking supplies organized mechanical energy, and friction or inelastic collisions dissipate it. Its kilogram-scale parts are not moved appreciably by molecular thermal fluctuations. Rectification requires broken spatial symmetry from the teeth or pawl and appropriate dynamical coupling: the shaking must sometimes disengage or drive the pawl over a tooth while contact and dissipation prevent equal reverse motion. The load must remain below the available mean driving torque. Isotropic, aperiodic shaking can satisfy these conditions because the asymmetric mechanism breaks directional symmetry; without the external energy supply, a working rectifier and dissipation, there is no guaranteed directed motion.

At fixed volume, logarithmic differentiation of the Saha ionization equation givesDifferentiation the internal energy then yieldsAt low temperature $\zeta \to 0$ and $C_V\to 3R/2$. At high nonrelativistic temperature the gas is fully ionized, $\zeta \to 1$, and $C_V\to 3R$. The large intermediate excess reflects energy spent increasing ionization, as well as heating and creating additional translational particles. “Very high” here remains below regimes where relativistic, radiative or pair-creation contributions invalidate the model.

Use quasineutrality, $n_e=Z{n}_i$. Multiplying the supplied collision time by the electron plasma frequency and using the preceding definition givesThus ${\tau }_{ei}\gg 2\pi /{\omega }_p$ requires $N_D\gg (2\pi /9.6)Z\ln \Lambda$; for ordinary $Z$ and $\ln \Lambda \sim 1$–$30$, this is a large plasma parameter. Many particles then collectively screen a charge, fluctuations in a Debye sphere are relatively small, and mean-field electrostatics descriptions become meaningful. A large plasma parameter is also associated with weak Coulomb coupling, well-separated screening and close-collision scales, and collective plasma oscillations surviving many oscillations before collisionally relaxing. Roughly, relative counting fluctuations scale as $N_D^{-1/2}$ and the ratio of interaction to thermal energy decreases as $N_D$ increases. Small $N_D$ signals that strong correlations can invalidate the simple weakly coupled plasma description.

The planetary equilibrium temperature is the effective planetary temperature at which absorbed starlight balances emitted thermal radiation, neglecting internal power. With uniform reradiation over the full surface,Cancelling areas givesUsing the supplied Bond albedos and taking the thermal emissivity $ϵ=1$ yields $\boxed{T_{\mathrm{eq},\oplus }\simeq 255\mathrm{K},T_{\mathrm{eq},\mathrm{J}}\simeq 103\mathrm{K}}$. “Perfect black bodies” must here mean perfect infrared emitters, since a perfect absorber at all wavelengths would instead have $\alpha =0$, inconsistent with retaining the supplied reflected fractions. If both albedos were set to zero, the corresponding values would be about $279$ and $122\mathrm{K}$.

Earth's mean surface temperature of about $288\mathrm{K}$ exceeds its emission temperature mainly because of the greenhouse effect. Jupiter also radiates substantial internal energy from cooling and contraction, including interior differentiation processes, so absorbed sunlight alone underpredicts its emission. Jupiter has no solid surface; the quoted $150\mathrm{K}$ is a representative atmospheric level and is not identical to an effective radiating temperature.

Protein primary structure is the ordered amino acid sequence of a polypeptide, linked by covalent peptide bonds. The approximately planar peptide bond restricts local geometry, while backbone torsion angles give conformational freedom subject to steric exclusion. Protein secondary structure comprises local backbone arrangements, especially the alpha helix, with backbone hydrogen bonds between residues $i$ and $i+4$, and the beta sheet, whose strands are joined by backbone hydrogen bonds. Turns and loops connect these elements. Protein tertiary structure is the full three-dimensional organization of a single chain, often including several protein domains. Protein quaternary structure is the arrangement of multiple chains in a protein complex.

Protein folding is governed by the Gibbs free energy of the chain together with its solvent, not by the chain's energy alone. Folding reduces the chain's conformational entropy, but can gain solvent entropy through the hydrophobic effect, burying nonpolar side chains away from water. Favorable hydrogen bonds, Van der Waals forces, electrostatic interactions and sometimes covalent disulfide bonds stabilize particular structures. Steric repulsion prevents atomic overlap. At fixed temperature and pressure, the native ensemble is favored when its total $\Delta G=\Delta H-T\Delta S$ is lower than competing ensembles. The balance depends on the solvent, pH, salt and ligands. Molecular chaperones help avoid aggregation or kinetic traps; a stable fold is not a perfectly rigid conformation, and some proteins have disordered regions.

For a soluble globular protein, a typical pattern is a nonpolar core and a polar, hydrated surface. A transmembrane protein instead presents nonpolar side chains to the hydrocarbon interior of the lipid bilayer. Membrane-spanning alpha helices satisfy their polar backbone groups through internal hydrogen bonds; a roughly membrane-thickness helix commonly contains about twenty residues, depending on tilt and bilayer thickness. Multiple helices can enclose polar channels or binding sites. Membrane-spanning beta barrels likewise expose mainly nonpolar groups outward towards lipid while arranging backbone hydrogen bonds between strands and often lining an aqueous pore with polar groups. Exposed loops and domains contacting water can resemble soluble proteins. Not every membrane-associated protein spans the membrane: peripheral attachment and lipid anchoring are distinct possibilities.

The organizing distinction is the environment of each surface: water favors accessible polar groups, while the membrane core favors outward-facing nonpolar groups. Buried polar groups can still be essential to a transport pathway or catalytic site.

Adiabatic expansion preserves the blackbody form while each photon's energy redshifts as $a^{-1}$. Thus the cosmic microwave background temperature obeys $T(z)=T_0(1+z)$, giving

For a fully ionized, nonrelativistic monatomic ideal gas, $\gamma =5/3$ and the virial theorem becomesSince $U$ increases with its particle-weighted mean temperature, the equilibrated self-gravitating object has negative heat capacity: adding total energy allows expansion, makes $\Omega$ less negative, and reduces $U$. Conversely, radiating energy permits contraction and raises the internal temperature. This refers to a sequence of gravitational equilibria, not to the positive local heat capacity of a parcel at fixed volume.

In an ordinary nondegenerate nuclear-burning star, a rise in nuclear heating tends to expand and cool the burning region, lowering its temperature-sensitive reaction rate. Reduced heating leads to contraction and reheating. This expansion feedback is the nuclear thermostat; it can fail in degenerate matter where pressure responds weakly to temperature. During contraction of a pre-main-sequence star, gravitational binding supplies the radiated luminosity and heats the interior. For a fixed-structure scaling, half the released gravitational energy increases $U$ and half escapes as radiation, until hydrogen burning can support a long-lived main sequence equilibrium.

Write $\Omega =-aG{M}_{\odot }^2/R_{\odot }$ with a structure factor $a$ of order unity. Then the thermal radiation timescale isFor a uniform sphere $a=3/5$, this is about $9.4\times 10^6$ years. The conventional Kelvin-Helmholtz cooling time $G{M}_{\odot }^2/(R_{\odot }{L}_{\odot })$ is about $3.1\times 10^7$ years; a centrally concentrated solar model changes the coefficient. Both estimates are far shorter than the nuclear lifetime.

Ionization and dissociation can store compression energy without the full temperature rise of a monatomic gas, lowering the effective adiabatic response in partially ionized outer layers. Radiation pressure tends towards an adiabatic exponent $4/3$. These effects, changing composition and degeneracy make the effective exponent position dependent. The local dynamical exponent is ${\Gamma }_1=(\partial \log P/\partial \log \rho {)}_s$; it equals $C_P/C_V$ in the simple fixed-composition ideal-gas model, but need not do so for an ionizing mixture.

If an envelope has an effective exponent at or below $4/3$, its pressure response is soft and sufficiently extensive such regions can promote radial pulsation, envelope instability or mass loss. In the ideal homologous global model, $\gamma =4/3$ is marginal and $\gamma <4/3$ is unstable to contraction or expansion. A low value confined to a thin outer layer does not by itself prove collapse of the entire star: global stability depends on the pressure-weighted structure. Its location and mass extent matter.

Near a red giant's compact core, intense nuclear burning in a small region can produce a large $L_r/m_r$ and a steep required radiative gradient. Where this exceeds the adiabatic gradient, convection transports the released energy and mixes fuel. Core helium burning is a clear example: the strongly temperature-sensitive Triple-alpha process commonly produces a convective burning core; shell flashes can also make convective regions.^[ref]

The qualification matters: an inert degenerate helium core and a steady hydrogen-burning shell on the first-ascent red giant branch are not universally convective; conduction or radiation may dominate there. Red giants also commonly have deep convective envelopes. The physical condition is an excessive required radiative gradient, not proximity to the centre alone.

Let $r$ be the electron-nucleus separation and use the reduced mass $\mu =m_{e}M/(m_e+M)$. Coulomb attraction supplies the relative centripetal force, and Bohr quantization fixes the relative angular momentum:Eliminating $v$ givesThe total energy is $E=\mu v^2/2-Z{e}^2/(4\pi {ϵ}_{0}r)=-Z{e}^2/(8\pi {ϵ}_{0}r)$, henceHere $a_0$ is the ordinary Bohr radius and $R_{\infty }$ the infinite-nuclear-mass Rydberg constant. The electron's radius about the centre of mass is $M{r}_n/(M+m_e)$; for a heavy nucleus this distinction and the reduced-mass correction are small, but the supplied nuclear mass permits them to be stated precisely.

The emitted photon carries the decrease in atomic energy, so $hc/\lambda =E_n-E_m$ for $n>m$. Using the preceding energy levels givesThe lower state's energy is more negative, making the right-hand side positive. This is the hydrogenic Rydberg formula, with the finite-nuclear-mass factor included in $R_M$.

The one-dimensional time-independent Schrödinger equation isThe differential term is the kinetic energy operator acting on the wave function, $V(x)$ supplies the multiplicative potential energy, and their sum is the Hamiltonian operator. The eigenvalue $E$ is the stationary state's total energy. This form assumes a nonrelativistic particle, a time-independent scalar potential, and no additional internal degrees of freedom in the stated model.

Each energy eigenstate acquires its own phase under the time-independent Hamiltonian operator:Orthonormality removes all off-diagonal terms from the expected value of the energy, givingReturn up to an overall phase requires the relative phase to return to one. For $E_1\ne E_2$, the shortest positive recurrence time isIf the two energies coincide, the whole superposition is stationary up to a common phase for every time; there is then no smallest strictly positive recurrence time. A half-period changes the relative sign and produces the orthogonal antisymmetric state rather than the original symmetric state.

Projection onto the antisymmetric quantum superposition gives amplitude $\frac{1}{2}(e^{-i{E}_{1}t/\hslash }-e^{-i{E}_{2}t/\hslash })$. Its squared modulus isIt vanishes initially, reaches one at a half-recurrence time, and returns to zero after $\tau$. This interference depends on a relative phase even though each energy-eigenstate population and the mean energy remain constant.