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Mendelian randomization uses inherited <genetic variants> associated with an <exposure> as <instrumental variables>. Its causal interpretation requires <instrument relevance>, <instrumental-variable independence>, and the <exclusion restriction>.


Mendelian randomization

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A genetic variant is a heritable difference in a DNA sequence relative to a chosen reference. Genetic variants can be used as <instrumental variables> in <Mendelian randomization> when the required causal assumptions are credible.


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 Incoming links: Genetic variant